Compare Compro vs. Sancuso

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Compro (Prochlorperazine)

Prescription only

Sancuso (granisetron)

Prescription only
Helps you feel less queasy.

Compro (Prochlorperazine) can be used to treat severe nausea and vomiting and can be taken orally or rectally, but get ready for a nap.

3.0/ 5 average rating with 20 reviewsforCompro
Helps reduce nausea and vomiting.

Sancuso (granisetron) is a good choice to reduce nausea and vomiting if it's hard for you to take oral medicines, but is very expensive.

Upsides
  • Available in generic, so it's cheap.
  • Can be taken by mouth, as a shot, or rectally.
  • Can take anywhere from 10 minutes (by shot) to 60 minutes (rectally) to start working.
  • Each Sancuso (granisetron) patch provides around-the-clock relief from nausea and vomiting for up to 7 days without having to re-dose and without problems associated with missing a dose.
  • May be a better option for some people on multi-day chemotherapy regimens.
Downsides
  • Can make you really drowsy. Drinking alcohol with it can make the drowsiness even worse.
  • Can't be used by people over 65 because they can be more affected by the side effects.
  • It can make you more likely to get heatstroke.
  • Must be applied at least 24 hours before the scheduled chemotherapy.
  • Sancuso (granisetron) has the possibility of interacting with antidepressants that can result in a dangerous build up of serotonin.
  • Must restrict from certain activites such as swimming and strenous excerise while wearing Sancuso (granisetron).
  • Should be used with caution in people with any heart condition.
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Used for
Dosage forms
  • Pill
  • Suppository
  • Patch
Price
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Reviews
20 reviews so far
45%
saidit'sworth it
35%
saiditworked well
35%
saidit'sa big hassle

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Side effects
The Compro (Prochlorperazine) FDA package insert doesn’t have numbers about how common side effects are.
The Sancuso (granisetron) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Increased risk of death
    • Over age 65
    • Dementia
    • Taking antipsychotics
  • Seizures
    • History of seizures
  • Involuntary muscle movements
    • Age over 65
  • Neuroleptic malignant syndrome
  • Heatstroke
  • Driving impairment
    • Taking with alcohol
    • Taking other medicines that make you less alert
See more detailed risks and warnings
  • Rare serious drug interaction
    • Taking other medicines that affect serotonin levels such as tramadol and anti-depressants
  • Heart disease
  • Masking of intestinal blockage and stomach bloating
  • Skin reactions
  • Heat exposure
    • Exposure to heat
  • Sun exposure
    • Exposure to sun
See more detailed risks and warnings