Compare Concerta vs. Vyvanse

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Helps you focus and stay alert.

Concerta (methylphenidate extended-release) is a first-choice treatment for ADHD that works throughout the day, but can affect growth in children and teens.

Helps you focus and stay alert.

Vyvanse (lisdexamfetamine) is a first-choice treatment for attention-deficit/hyperactivity disorder, but it can be expensive since it's only available as a brand name product.

3.7/ 5 average rating with 491 reviewsforVyvanse
Upsides
  • First-choice medication to treat ADHD. Some other forms of Concerta (methylphenidate extended-release) can also treat narcolepsy.
  • The onset of effects will occur within an hour. The full effects can last 8 to 12 hours.
  • Taken only once a day compared to the immediate-release form.
  • Available in many different forms: extended-release and immediate-release tablets, chewable tablet, liquid, and skin patches.
  • The capsule may be sprinkled on applesauce if you have a difficult time swallowing pills.
  • Vyvanse (lisdexamfetamine) is a first-choice medication to treat attention-deficit/hyperactivity disorder (ADHD).
  • It is usually dosed once a day, so parents don't need to send the medication with their children to school.
  • Can take the capsule as a whole or mix the contents with water, orange juice, or yogurt.
  • Available as a chewable pill form.
Downsides
  • Avoid alcohol since it can cause worsen side effects.
  • Concerta (methylphenidate extended-release) is a controlled medication that can be habit-forming and lead to physical dependence.
  • Cannot stop taking this drug all of a sudden without calling your doctor. You may have a greater risk of mood changes.
  • Need to take Vyvanse (lisdexamfetamine) in the morning, otherwise it can cause difficulty sleeping at night.
  • Vyvanse (lisdexamfetamine) is not available as a generic medication, so it is expensive.
  • This medicine has the potential for abuse and dependence.
  • Can cause serious side effects for the heart.
  • Can also slow growth in children and cause weight loss.
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Used for
Dosage forms
  • Pill
  • Chewable tablet
  • Dissolving tablet
  • Liquid
  • Pill
Price
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Reviews
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491 reviews so far
67%
saidit'sworth it
49%
saiditworked well
17%
saidit'sa big hassle

Have you used Vyvanse (lisdexamfetamine)?

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Side effects
30possible side effects
  • Lowered appetite
    25%
  • Headache
    22%
  • Dry mouth
    14%
  • Nausea
    13%
  • Loss of sleep
    12%
  • Anxiety
    8%
  • Weight loss
    7%
  • Dizziness
    7%
  • Irritability
    6%
  • Fast heart rate
    5%
  • Excessive sweating
    5%
  • Initial insomnia
    4%
  • Depressed mood
    4%
  • Palpitations
    3%
  • Tremor
    3%
  • Nervousness
    3%
  • Restlessness
    3%
  • Vertigo
    2%
  • Blurred vision
    2%
  • Indigestion
    2%
  • Vomiting
    2%
  • Upper respiratory tract infection
    2%
  • Inability to eat
    2%
  • Muscle tightness
    2%
  • Agitation
    2%
  • Aggression
    2%
  • Teeth grinding
    2%
  • Depression
    2%
  • Low sex drive
    2%
  • Mouth and throat pain
    2%
See more detailed side effects
15possible side effects
  • Decreased appetite
    27%
  • Difficulty sleeping
    27%
  • Dry mouth
    26%
  • Diarrhea
    7%
  • Nausea
    7%
  • Anxiety
    6%
  • Loss of appetite
    5%
  • Feeling jittery
    4%
  • Agitation
    3%
  • Increased blood pressure
    3%
  • Sweating
    3%
  • Restlessness
    3%
  • Difficulty breathing
    2%
  • Increased heart rate
    2%
  • Tremor
    2%
See more detailed side effects
Risks and risk factors
  • Serious or life-threatening heart problems
    • History of heart problems
  • Abuse and dependence
    • History of drug abuse
    • Alcoholism
  • Aggressive behavior and psychiatric symptoms
    • History of psychotic episodes
    • History of bipolar disorder
    • History of Tourette's syndrome
  • Long-term growth suppression
    • Children
  • Seizures
    • History of seizures
  • Circulation problems in the hands and feet
See more detailed risks and warnings
  • High blood pressure
    • Taking monoamine oxidase inhibitors (MAOI) 14 days before starting Vyvanse (lisdexamfetamine)
  • Abuse and dependence
    • History of drug abuse
  • Serious or life-threatening cardiovascular events
    • History of heart problems
  • Aggressive behavior and psychosis
    • History of psychotic episodes
    • History of bipolar disorder
  • Long-term growth suppression
    • Children ages 6 to 12
See more detailed risks and warnings