Compare Coumadin vs. Eliquis

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Coumadin (warfarin)

Prescription only

Eliquis (apixaban)

Prescription only
Prevents blood clots.

Coumadin (warfarin) is a cheap and effective medicine that prevents new blood clots. It requires regular blood tests and you'll need to eat, exercise, and take your medicines consistently.

3.8/ 5 average rating with 513 reviewsforCoumadin
Prevents blood clots.

Eliquis (apixaban) is an effective way to prevent blood clots from forming in your veins, but you have to take it twice a day, and your doctor might have to change the dose a lot.

3.8/ 5 average rating with 19 reviewsforEliquis
Upsides
  • Coumadin (warfarin) is available as a generic, so it should be less expensive than the brand version.
  • In case you start bleeding too much while using Coumadin (warfarin), your doctor can give you another drug that reverses Coumadin (warfarin)'s effects.
  • Coumadin (warfarin) comes in numerous strengths.
  • Coumadin (warfarin) has been around for a long time and is one of the most commonly used 'blood thinner' medicines.
  • Eliquis (apixaban) is very effective in reducing the risk of stroke in people with atrial fibrilation or other clotting disorders.
  • You don't need to have regular blood tests on Eliquis (apixaban), and you don't have to regulate your diet like other blood thinners.
  • If you've had clots in your legs or lungs before, Eliquis (apixaban) can lower the risk of these forming again.
Downsides
  • Raises your risk of bleeding and bruising.
  • Requires regular blood work, such as an INR, to make sure Coumadin (warfarin) is working correctly.
  • Your daily dose of Coumadin (warfarin) can change if you change your diet, exercise patterns, or use of alcohol.
  • A lot of other drugs and supplements interact with Coumadin (warfarin), so you'll need to check with your doctor or pharmacist before starting any new medicines.
  • You can bruise easier and if you cut yourself, it'll take longer to stop the bleeding. Always look for signs of internal bleeding, such as dark urine or bloody stools.
  • Can't be used if you have artificial heart valves.
  • Never stop taking Eliquis (apixaban) without talking to your doctor first.
  • Eliquis (apixaban) isn't available as a generic, so it can be expensive.
  • If you've taken too much Eliquis (apixaban) and you're bleeding, it can be harder to treat compared to other blood thinners.
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Used for
Dosage forms
  • Pill
  • Pill
Price
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Reviews
513 reviews so far
61%
saidit'sworth it
54%
saiditworked well
21%
saidit'sa big hassle

Have you used Coumadin (warfarin)?

Leave a review
19 reviews so far
47%
saidit'sworth it
58%
saiditworked well
21%
saidit'sa big hassle

Have you used Eliquis (apixaban)?

Leave a review
Side effects
The Coumadin (warfarin) FDA package insert doesn’t have numbers about how common side effects are.
1possible side effects
  • Major bleed
    2%
See more detailed side effects
Risks and risk factors
  • Life threatening bleeding
    • Coumadin (warfarin) dose too high
    • Age greater than 65 year
    • History of stomach bleeding
    • High blood pressure
    • Kidney or liver problems
    • Drug interactions
    • Change in lifestyle or diet
    • Alcohol use
    • Certain genetic factors
  • Harm to fetus
    • Women of childbearing age
  • Drug and diet interactions
  • Potential surgery or amputation
See more detailed risks and warnings
  • Increased risk of stroke or blood clots from early discontinuation
    • Stopping Eliquis (apixaban) prematurely
  • Paralysis in the spine
    • Spinal puncture (spinal tap)
    • Getting anesthesia in the spine (epidural anesthesia)
    • History of spinal surgery
    • Concomitant use of nonsteroidal anti-inflammatory drugs (NSAIDs), or other blood-thinners
  • Interactions with other drugs
  • Increased risk of stroke or bleeding
    • Artificial heart valve
  • Increased side effects in kidney or liver conditions
    • Current kidney problems
    • Current liver problems
See more detailed risks and warnings