Compare Cresemba vs. Noxafil

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Noxafil (posaconazole)

Prescription only
Treats serious fungal infections.

Cresemba (isavuconazonium) is used to treat serious fungal infections as an alternative if you had problems with first choice medicines. However, it can be very expensive.

Treats and prevents fungal infections.

Noxafil (posaconazole) works against many different fungal infections, but may require close follow-up for potential side effects and drug interactions.

Upsides
  • Unlike some other antifungal medications, you don’t need regular blood tests while you're taking Cresemba (isavuconazonium).
  • Cresemba (isavuconazonium) has fewer and milder side effects than other medicines for fungal infections.
  • You only need to take Cresemba (isavuconazonium) once a day after the first two days.
  • If you have conditions related to a slow or abnormal heartbeat, Cresemba (isavuconazonium) may be a good choice for treatment of a serious fungal infection.
  • Available in both an injectable form and capsules you take by mouth.
  • Noxafil (posaconazole) works against more types of fungal infections than other medications like it.
  • Available in liquid form if you have difficulty swallowing pills.
Downsides
  • Cresemba (isavuconazonium) needs to be taken twice daily.
  • Cresemba (isavuconazonium) may cause serious blood, muscle and liver problems.
  • Cresemba (isavuconazonium) is not recommended if you have kidney damage.
  • Cresemba (isavuconazonium) has a high incidence of side effects, including nausea, vomiting, loss of appetite, headache and malaise.
  • Cresemba (isavuconazonium) can negatively affect your cholesterol and blood sugar levels.
  • Available as brand version only so may be more expensive than other medications like it.
  • Noxafil (posaconazole) has many drug interactions.
  • The pill and liquid forms are not readily interchangeable without your doctor's help.
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Used for
  • Invasive aspergillosis
  • Invasive mucormycosis
  • Prevention of fungal infection.
  • Treatment of fungal infection in the mouth or throat
Dosage forms
  • Pill
  • Injection
  • Extended release pill
  • Liquid
Price
Lowest price
$5121.54
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Lowest price
$6092.22
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Reviews
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Side effects
25possible side effects
  • Nausea
    28%
  • Vomiting
    25%
  • Diarrhea
    24%
  • Low potassium
    19%
  • Abdominal pain
    17%
  • Headache
    17%
  • Changes in liver blood tests
    17%
  • Trouble breathing
    17%
  • Swelling in the arms and legs
    15%
  • Constipation
    14%
  • Insomnia
    11%
  • Fatigue
    11%
  • Kidney failure
    10%
  • Back pain
    10%
  • Chest pain
    9%
  • Decreased appetite
    9%
  • Confusion/delirium
    9%
  • Skin rash
    9%
  • Itching
    8%
  • Low blood pressure
    8%
  • Anxiety
    8%
  • Acute respiratory failure
    7%
  • Indigestion
    6%
  • Injection site reactions
    6%
  • Low magnesium
    5%
See more detailed side effects
16possible side effects
  • Diarrhea
    10%
  • Nausea
    9%
  • Headache
    8%
  • Vomiting
    7%
  • Fever
    6%
  • Abdominal pain
    5%
  • Low white blood cells
    4%
  • Fatigue
    3%
  • Herpes simplex
    3%
  • Lung infection
    3%
  • Coughing
    3%
  • Rash
    3%
  • Anorexia
    2%
  • Weakness
    2%
  • Low red blood cells
    2%
  • Increased sweating
    2%
See more detailed side effects
Risks and risk factors
  • Liver problems
  • Infusion problems
  • Severe allergic reactions
  • Risks to fetus
    • Pregnancy
  • Drug interactions
See more detailed risks and warnings
  • Abnormal heartbeat
    • QT prolongation
    • Arrhythmia
    • Drugs that cause prolonged QT interval
    • Abnormal electrolytes
  • Liver problems
    • Blood disorder
    • Liver disease
  • Kidney problems
    • Kidney problems
    • Kidney disease
  • Drug toxicity
See more detailed risks and warnings