Compare Cresemba vs. Vfend

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Vfend (voriconazole)

Prescription only
Treats serious fungal infections.

Cresemba (isavuconazonium) is used to treat serious fungal infections as an alternative if you had problems with first choice medicines. However, it can be very expensive.

Treats fungal infections.

Vfend (voriconazole) is effective at treating many different fungal infections, but it can cause blurry vision and make your eyes more sensitive to light.

Upsides
  • Unlike some other antifungal medications, you don’t need regular blood tests while you're taking Cresemba (isavuconazonium).
  • Cresemba (isavuconazonium) has fewer and milder side effects than other medicines for fungal infections.
  • You only need to take Cresemba (isavuconazonium) once a day after the first two days.
  • If you have conditions related to a slow or abnormal heartbeat, Cresemba (isavuconazonium) may be a good choice for treatment of a serious fungal infection.
  • Available in both an injectable form and capsules you take by mouth.
  • Vfend (voriconazole) is good for treating infections caused by many different types of fungi.
  • Available as a generic, and in both tablet and liquid form.
  • Vfend (voriconazole) is the antifungal drug of choice to treat Aspergillosis infection.
Downsides
  • Cresemba (isavuconazonium) needs to be taken twice daily.
  • Cresemba (isavuconazonium) may cause serious blood, muscle and liver problems.
  • Cresemba (isavuconazonium) is not recommended if you have kidney damage.
  • Cresemba (isavuconazonium) has a high incidence of side effects, including nausea, vomiting, loss of appetite, headache and malaise.
  • Cresemba (isavuconazonium) can negatively affect your cholesterol and blood sugar levels.
  • Vfend (voriconazole) can cause blurry vision and sensitity to bright lights.
  • Vfend (voriconazole) cannot be taken with food.
  • Your skin may become more sensitive to the sun while taking Vfend (voriconazole). Make sure to use sunscreen or wear protective layers.
  • Vfend (voriconazole) has a lot of drug interactions.
  • Vfend (voriconazole) isn't absorbed in the same way by everyone, so you'll probably need to get regular blood tests while taking it.
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Used for
  • Invasive aspergillosis
  • Invasive mucormycosis
  • Aspergillosis
  • Candidemia
  • Candidiasis of the esophagus
  • Disseminated candidiasis
  • Mycosis
  • Allergic bronchopulmonary aspergillosis
  • Aspergillosis prophylaxis
  • Blastomycosis
  • Febrile neutropenia
  • Oropharyngeal candidiasis
  • Pulmonary aspergillosis
Dosage forms
  • Pill
  • Injection
  • Pill
  • Liquid
Price
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Reviews
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Side effects
25possible side effects
  • Nausea
    28%
  • Vomiting
    25%
  • Diarrhea
    24%
  • Low potassium
    19%
  • Abdominal pain
    17%
  • Headache
    17%
  • Changes in liver blood tests
    17%
  • Trouble breathing
    17%
  • Swelling in the arms and legs
    15%
  • Constipation
    14%
  • Insomnia
    11%
  • Fatigue
    11%
  • Kidney failure
    10%
  • Back pain
    10%
  • Chest pain
    9%
  • Decreased appetite
    9%
  • Confusion/delirium
    9%
  • Skin rash
    9%
  • Itching
    8%
  • Low blood pressure
    8%
  • Anxiety
    8%
  • Acute respiratory failure
    7%
  • Indigestion
    6%
  • Injection site reactions
    6%
  • Low magnesium
    5%
See more detailed side effects
11possible side effects
  • Abnormal vision
    19%
  • Fever
    6%
  • Nausea
    5%
  • Rash
    5%
  • Chills
    4%
  • Vomiting
    4%
  • Headache
    3%
  • Abnormal liver tests
    3%
  • Sensitivity to light
    2%
  • Fast heart rate
    2%
  • Hallucinations
    2%
See more detailed side effects
Risks and risk factors
  • Liver problems
  • Infusion problems
  • Severe allergic reactions
  • Risks to fetus
    • Pregnancy
  • Drug interactions
See more detailed risks and warnings
  • Liver problems
    • Blood disorder
    • Liver disease
  • Abnormal vision or eye sensitivity
  • Abnormal heartbeat
    • QT prolongation
    • Arrhythmia
    • Drugs that cause prolonged QT interval
    • Abnormal electrolytes
  • Gallbladder problems
    • History of gallblader disease
    • People with severe kidney problems
  • Pancreas problems (pancreatitis)
  • Skin reaction to light
    • Children
See more detailed risks and warnings