Compare Crestor vs. Lopid

Head-to-head comparisons of medication uses, side effects, ratings, and more.


Crestor (rosuvastatin)

Prescription only

Lopid (gemfibrozil)

Prescription only
Lowers cholesterol.

Crestor (rosuvastatin) is one of the most effective statins to improve cholesterol. It's also available as a generic.

3.7/ 5 average rating with 751 reviewsforCrestor
Lowers cholesterol and triglyceride levels.

Lopid (gemfibrozil) works well to lower triglycerides and bad cholesterol, but it may not be the best option if you're also on a statin drug.

  • It's a good first choice medicine for lowering cholesterol levels when diet and exercise aren't enough.
  • Slows down the buildup of fatty deposits in your blood vessels, otherwise known as a hardening of the arteries.
  • In clinical studies, Crestor (rosuvastatin) has the strongest effect on lowering "bad" cholesterol compared to other statins.
  • Can lower your risk of heart attack, stroke, and death, particularly if you have diabetes, high blood pressure, obesity, or a history of smoking.
  • Available as a generic drug.
  • Lopid (gemfibrozil) is available as a generic.
  • It can significantly lower your triglycerides and bad cholesterol (LDL), and raise your good cholesterol (HDL).
  • More effective and causes fewer side effects than non-statin cholesterol-lowering medicines.
  • You're more likely to have side effects if you're a female, are 65 years or older, drink alcohol every day, or take more than one medicine for cholesterol.
  • People with liver disease, kidney disease, or diabetes are also more likely to have side effects from Crestor (rosuvastatin).
  • Crestor (rosuvastatin) isn't safe to use if you're pregnant since it can hurt the fetus.
  • Since so many people use statin medications to treat their cholesterol, Lopid (gemfibrozil) isn't generally the first choice treatment to use since it can interact with statins.
  • Can be more expensive than some alternative medicines.
  • Need to take Lopid (gemfibrozil) twice a day, whereas other similar medications are only once a day.
Used for
Dosage forms
  • Pill
  • Pill
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Side effects
The Crestor (rosuvastatin) FDA package insert doesn’t have numbers about how common side effects are.
9possible side effects
  • Stomach and intestinal problems
  • Stomach upset
  • Abdominal pain
  • Diarrhea
  • Fatigue
  • Nausea or vomiting
  • Eczema
  • Rash
  • Feeling off balance
See more detailed side effects
Risks and risk factors
  • Elevated INR
    • Taking Coumadin (warfarin)
  • Muscle pain
    • Age 65 or older
    • Taking higher doses of Crestor (rosuvastatin)
  • Increased blood sugars
    • Diabetes
  • Liver damage
    • Heavy alcohol use
    • Prior history of chronic liver disease
  • Birth defects
    • Pregnancy
See more detailed risks and warnings
  • Muscle pain
    • Taking Lopid (gemfibrozil) with statins
  • Liver problems
    • Past history of liver disease
  • Kidney problems
    • Kidney problems
  • Bleeding risk
    • Taking Lopid (gemfibrozil) with anticoagulants
  • Breastfeeding
  • Gallstones
See more detailed risks and warnings