Compare Crestor vs. Praluent

Head-to-head comparisons of medication uses, side effects, ratings, and more.


Crestor (rosuvastatin)

Prescription only

Praluent (alirocumab)

Prescription only
Lowers cholesterol.

Crestor (rosuvastatin) is one of the most effective statins to improve cholesterol. It's also available as a generic.

3.7/ 5 average rating with 751 reviewsforCrestor
Lowers cholesterol.

If diet, exercise and statin medications aren't lowering your cholesterol enough, using Praluent (alirocumab) with them can help.

  • It's a good first choice medicine for lowering cholesterol levels when diet and exercise aren't enough.
  • Slows down the buildup of fatty deposits in your blood vessels, otherwise known as a hardening of the arteries.
  • In clinical studies, Crestor (rosuvastatin) has the strongest effect on lowering "bad" cholesterol compared to other statins.
  • Can lower your risk of heart attack, stroke, and death, particularly if you have diabetes, high blood pressure, obesity, or a history of smoking.
  • Available as a generic drug.
  • Praluent (alirocumab) is effective in lowering bad cholesterol in people with heart problems due to plaque in their arteries or people who inherited bad cholesterol (HeFH).
  • Many health insurance and Medicare plans cover the cost of Praluent (alirocumab). If you are uninsured, Praluent (alirocumab) has a Patient Assistance Program that may be able to cover the cost.
  • You don't have to take Praluent (alirocumab) every day. It's taken every 2 weeks or once a month, for some.
  • You're more likely to have side effects if you're a female, are 65 years or older, drink alcohol every day, or take more than one medicine for cholesterol.
  • People with liver disease, kidney disease, or diabetes are also more likely to have side effects from Crestor (rosuvastatin).
  • Crestor (rosuvastatin) isn't safe to use if you're pregnant since it can hurt the fetus.
  • Praluent (alirocumab) should be taken with other cholesterol-lowering drugs. The two drugs work together to lower your bad cholesterol.
  • You must take care to keep Praluent (alirocumab) cool if you're traveling or away from home. You may pack it in a travel cooler but do not freeze your Praluent (alirocumab).
  • Praluent (alirocumab) only comes as an injection.
  • You can only use each Praluent (alirocumab) pen once. This can become expensive.
Used for
Dosage forms
  • Pill
  • Injection
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Side effects
The Crestor (rosuvastatin) FDA package insert doesn’t have numbers about how common side effects are.
12possible side effects
  • Common cold
  • Injection site reaction
  • Influenza
  • Urinary tract infection
  • Diarrhea
  • Bronchitis
  • Muscle pain
  • Muscle spasms
  • Sinus infection
  • Cough
  • Confusion
  • Pain in bones, joints, and muscles
See more detailed side effects
Risks and risk factors
  • Elevated INR
    • Taking Coumadin (warfarin)
  • Muscle pain
    • Age 65 or older
    • Taking higher doses of Crestor (rosuvastatin)
  • Increased blood sugars
    • Diabetes
  • Liver damage
    • Heavy alcohol use
    • Prior history of chronic liver disease
  • Birth defects
    • Pregnancy
See more detailed risks and warnings