Compare Crestor vs. Welchol

Head-to-head comparisons of medication uses, side effects, ratings, and more.


Crestor (rosuvastatin)

Prescription only

Welchol (colesevelam)

Prescription only
Lowers cholesterol.

Crestor (rosuvastatin) is one of the most effective statins to improve cholesterol. It's also available as a generic.

3.7/ 5 average rating with 751 reviewsforCrestor
Lowers cholesterol and helps lower blood sugars.

Can be taken as a tablet or as a sprinkled packet that's mixed with water, juice, or diet soft drinks.|Welchol (colesevelam) may be a good option for people who have high cholesterol and diabetes.|Welchol (colesevelam) is another option for people that can't tolerate statin medications.|It's able to be used in children over the age of 10.

  • It's a good first choice medicine for lowering cholesterol levels when diet and exercise aren't enough.
  • Slows down the buildup of fatty deposits in your blood vessels, otherwise known as a hardening of the arteries.
  • In clinical studies, Crestor (rosuvastatin) has the strongest effect on lowering "bad" cholesterol compared to other statins.
  • Can lower your risk of heart attack, stroke, and death, particularly if you have diabetes, high blood pressure, obesity, or a history of smoking.
  • Available as a generic drug.
  • Can be taken as a tablet or a sprinkled packet that's mixed with water, juice, or diet soft drinks.
  • Welchol (colesevelam) may be good for people with high cholesterol and diabetes since it can help with both conditions.
  • Welchol (colesevelam) is a good option for people that can't tolerate statins.
  • You're more likely to have side effects if you're a female, are 65 years or older, drink alcohol every day, or take more than one medicine for cholesterol.
  • People with liver disease, kidney disease, or diabetes are also more likely to have side effects from Crestor (rosuvastatin).
  • Crestor (rosuvastatin) isn't safe to use if you're pregnant since it can hurt the fetus.
  • Welchol (colesevelam) can make you feel really constipated.
  • Welchol (colesevelam) doesn't lower cholesterol as well as other drugs.
  • It interacts with many other medications by reducing their absorption in the body.
  • Welchol (colesevelam) can increase the amount of triglycerides (fats) in some people, so your doctor may perform blood work to check your triglyceride levels.
  • It's not recommended for use in children under 10 years of age.
Used for
  • High cholesterol
  • Diabetes
  • Hereditary high cholesterol (Heterozygous familial hypercholesterolemia)
Dosage forms
  • Pill
  • Pill
  • Powder
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751 reviews so far
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Side effects
The Crestor (rosuvastatin) FDA package insert doesn’t have numbers about how common side effects are.
6possible side effects
  • Constipation
  • Low blood sugar
  • Indigestion
  • Nausea
  • High blood pressure
  • Back pain
See more detailed side effects
Risks and risk factors
  • Elevated INR
    • Taking Coumadin (warfarin)
  • Muscle pain
    • Age 65 or older
    • Taking higher doses of Crestor (rosuvastatin)
  • Increased blood sugars
    • Diabetes
  • Liver damage
    • Heavy alcohol use
    • Prior history of chronic liver disease
  • Birth defects
    • Pregnancy
See more detailed risks and warnings
  • Bowel obstruction or blockage
    • Gastrointestinal tract surgery
    • Gastroparesis
    • Gastric motility disorders
  • Pancreatitis
    • People with high triglycerides (TG 300-500)
    • History of hypertriglyceride-induced pancreatitis
    • History of diabetes
  • Vitamin deficiencies
  • Drug interactions
  • Swallowing issues
    • Problems with swallowing large pills
See more detailed risks and warnings