Compare Cymbalta vs. Depakote
Head-to-head comparisons of medication uses, side effects, ratings, and more.
Improves mood and relieves certain types of pain.
Cymbalta (duloxetine) is good for treating depression, anxiety, and some forms of chronic pain, but it is more likely than other antidepressants to cause problems if you drink alcohol or have high blood pressure.
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3.6/ 5 average rating with 496 reviewsforCymbalta
Treats and prevents seizures, and stabilizes mood.
Depakote (divalproex) is good for long-term prevention of seizures, manic episodes in bipolar disorder, and migraines.
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3.3/ 5 average rating with 97 reviewsforDepakote
Upsides
- Cymbalta (duloxetine) may help relieve nerve pain from diabetes and other forms of chronic pain.
- Cymbalta (duloxetine) has several uses, which may be good for people with multiple conditions.
- Available as a generic, which is cheaper.
- Lowers the frequency of seizures, especially for people with absence seizures or complex partial seizures.
- Depakote (divalproex) is a first-line treatment to stabilize mood for people with bipolar disorder.
- Depakote (divalproex) is helpful for preventing frequent migraines.
- The sprinkle pill can be swallowed whole or can be opened up and mixed with applesauce if you have a hard time swallowing.
- Depakote (divalproex) is available as a generic.
Downsides
- Cymbalta (duloxetine) may not be a good option if you're a heavy drinker, or have liver or kidney problems.
- Cymbalta (duloxetine) can increase high blood pressure.
- Like most antidepressants, Cymbalta (duloxetine) can cause higher risk of suicidal thoughts and behavior for people aged 24 and younger.
- It can take 3 to 4 weeks before you feel the full effects of Depakote (divalproex).
- Depakote (divalproex) is not a good medication for people with liver problems.
- Requires regular blood tests to see how the medication is affecting your body.
- Depakote (divalproex) can make you bleed more easily.
Used for
- Depression
- Anxiety
- Diabetic neuropathy (nerve damage)
- Fibromyalgia
- Chronic muscle pain
- Urinary incontinence (women)
Dosage forms
- Pill
- Extended release
- Pill
- Extended release pill
- Delayed release pill
Price
Lowest price
$9.00
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$29.62
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Reviews
496 reviews so far
58%
saidit'sworth it
49%
saiditworked well
24%
saidit'sa big hassle
Have you used Cymbalta (duloxetine)?
Leave a review97 reviews so far
46%
saidit'sworth it
40%
saiditworked well
27%
saidit'sa big hassle
Have you used Depakote (divalproex)?
Leave a reviewSide effects
12possible side effects
- Nausea23%
- Headache14%
- Dry mouth13%
- Drowsiness10%
- Fatigue9%
- Difficulty sleeping9%
- Constipation9%
- Dizziness9%
- Diarrhea9%
- Decreased appetite7%
- Excessive sweating6%
- Abdominal pain5%
9possible side effects
- Nausea22%
- Sleepiness19%
- Dizziness12%
- Vomiting12%
- Accidental injury11%
- Feeling weak10%
- Abdominal pain9%
- Upset stomach9%
- Rash6%
Risks and risk factors
- Suicidal thoughts or behavior
- Age 24 years or younger
- Serotonin syndrome
- Taking tricyclic antidepressants, lithium, tramadol, fentanyl, amphetamines, certain headache medications (triptans), St. John's Wort
- Withdrawal
- Stopping Cymbalta (duloxetine) abruptly
- Increased bleeding
- Taking other blood-thinning drugs (including aspirin, NSAIDs such as Advil, warfarin)
- Changes in blood pressure and risk of falls
- Elderly patients
- History of gait disturbances
- Taking more than 60 mg of Cymbalta (duloxetine) daily
- Taking other medicines that lower blood pressure
- History of high blood pressure
- Bipolar disorder
- History of bipolar disorder
- At risk for bipolar disorder
- Harm to fetus
- Liver damage
- Children under age 2
- History of metabolic disorders
- Severe seizure disorder
- Brain disease
- History of liver problems
- Pancreas problems
- Suicidal thoughts or behavior
- History of depression
- Increased bleeding
- Mental changes
- History of metabolic disorders
- People also taking Topamax