Compare Cymbalta vs. Klonopin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Cymbalta (duloxetine)

Prescription only

Klonopin (clonazepam)

Prescription only
Improves mood and relieves certain types of pain.

Cymbalta (duloxetine) is good for treating depression, anxiety, and some forms of chronic pain, but it is more likely than other antidepressants to cause problems if you drink alcohol or have high blood pressure.

3.6/ 5 average rating with 496 reviewsforCymbalta
Controls seizures and helps panic attacks.

Klonopin (clonazepam) can be used for immediate relief of panic attacks and seizures, but is not intended for long-term management.

3.8/ 5 average rating with 767 reviewsforKlonopin
Upsides
  • Cymbalta (duloxetine) may help relieve nerve pain from diabetes and other forms of chronic pain.
  • Cymbalta (duloxetine) has several uses, which may be good for people with multiple conditions.
  • Available as a generic, which is cheaper.
  • More people who took Klonopin (clonazepam) were free of panic attacks, compared to people who did not take Klonopin (clonazepam).
  • Klonopin (clonazepam) works quickly, within the hour.
  • Can be used together with antidepressants to manage panic disorder.
  • Klonopin (clonazepam) lasts longer and has less severe withdrawal symptoms compared to other similar medicines.
Downsides
  • Cymbalta (duloxetine) may not be a good option if you're a heavy drinker, or have liver or kidney problems.
  • Cymbalta (duloxetine) can increase high blood pressure.
  • Like most antidepressants, Cymbalta (duloxetine) can cause higher risk of suicidal thoughts and behavior for people aged 24 and younger.
  • Klonopin (clonazepam) can cause memory problems, drowsiness, dizziness, and confusion.
  • Klonopin (clonazepam) can be habit-forming, so is not typically used for long-term treatment.
  • May require higher doses of Klonopin (clonazepam) over time to establish the same seizure control.
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Used for
Dosage forms
  • Pill
  • Extended release
  • Pill
  • Dissolving tablet
Price
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Reviews
496 reviews so far
58%
saidit'sworth it
49%
saiditworked well
24%
saidit'sa big hassle

Have you used Cymbalta (duloxetine)?

Leave a review
767 reviews so far
70%
saidit'sworth it
52%
saiditworked well
14%
saidit'sa big hassle

Have you used Klonopin (clonazepam)?

Leave a review
Side effects
12possible side effects
  • Nausea
    23%
  • Headache
    14%
  • Dry mouth
    13%
  • Drowsiness
    10%
  • Fatigue
    9%
  • Difficulty sleeping
    9%
  • Constipation
    9%
  • Dizziness
    9%
  • Diarrhea
    9%
  • Decreased appetite
    7%
  • Excessive sweating
    6%
  • Abdominal pain
    5%
See more detailed side effects
4possible side effects
  • Drowsiness
    37%
  • Depression
    7%
  • Abnormal coordination
    6%
  • Loss of full control of bodily movements
    5%
See more detailed side effects
Risks and risk factors
  • Suicidal thoughts or behavior
    • Age 24 years or younger
  • Serotonin syndrome
    • Taking tricyclic antidepressants, lithium, tramadol, fentanyl, amphetamines, certain headache medications (triptans), St. John's Wort
  • Withdrawal
    • Stopping Cymbalta (duloxetine) abruptly
  • Increased bleeding
    • Taking other blood-thinning drugs (including aspirin, NSAIDs such as Advil, warfarin)
  • Changes in blood pressure and risk of falls
    • Elderly patients
    • History of gait disturbances
    • Taking more than 60 mg of Cymbalta (duloxetine) daily
    • Taking other medicines that lower blood pressure
    • History of high blood pressure
  • Bipolar disorder
    • History of bipolar disorder
    • At risk for bipolar disorder
See more detailed risks and warnings
  • Sedation, respiratory depression, coma and death
    • Taking with opioids
    • Drinking alcohol
  • Dependence and withdrawal
    • Taking high dosage
    • Taking long-term
    • History of drug abuse
  • Driving impairment
    • Drinking alcohol
    • Taking other medicines that make you less alert
  • Suicidal behavior and ideation
See more detailed risks and warnings