Compare Cymbalta vs. nefazodone
Head-to-head comparisons of medication uses, side effects, ratings, and more.
Improves mood and relieves certain types of pain.
Cymbalta (duloxetine) is good for treating depression, anxiety, and some forms of chronic pain, but it is more likely than other antidepressants to cause problems if you drink alcohol or have high blood pressure.
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3.6/ 5 average rating with 496 reviewsforCymbalta
Treats depression.
Serzone (nefazodone) is usually used with other medicines to treat depression, but it is more likely to cause liver damage.
Upsides
- Cymbalta (duloxetine) may help relieve nerve pain from diabetes and other forms of chronic pain.
- Cymbalta (duloxetine) has several uses, which may be good for people with multiple conditions.
- Available as a generic, which is cheaper.
- Serzone (nefazodone) is a good choice to take with other medicines for depression if they haven't worked by themselves.
- Serzone (nefazodone) is available in generic.
Downsides
- Cymbalta (duloxetine) may not be a good option if you're a heavy drinker, or have liver or kidney problems.
- Cymbalta (duloxetine) can increase high blood pressure.
- Like most antidepressants, Cymbalta (duloxetine) can cause higher risk of suicidal thoughts and behavior for people aged 24 and younger.
- While Serzone (nefazodone) is available as a generic, it's not considered a first or second choice medicine for depression because it is more likely to cause liver damage than other similar medicines.
- Serzone (nefazodone) is usually taken 2 times a day; the first choice medicines are only taken 1 time a day.
- It can take up to 3 months before you notice the full effects of Serzone (nefazodone).
- Compared to other similar medicines, Serzone (nefazodone) has a lot of interactions with other drugs, so your doctor might have to adjust the doses of your other medicines.
Used for
- Depression
- Anxiety
- Diabetic neuropathy (nerve damage)
- Fibromyalgia
- Chronic muscle pain
- Urinary incontinence (women)
Dosage forms
- Pill
- Extended release
- Pill
Price
Lowest price
$12.65
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$31.97
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Reviews
496 reviews so far
58%
saidit'sworth it
49%
saiditworked well
24%
saidit'sa big hassle
Have you used Cymbalta (duloxetine)?
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Side effects
12possible side effects
- Nausea23%
- Headache14%
- Dry mouth13%
- Drowsiness10%
- Fatigue9%
- Difficulty sleeping9%
- Constipation9%
- Dizziness9%
- Diarrhea9%
- Decreased appetite7%
- Excessive sweating6%
- Abdominal pain5%
42possible side effects
- Headache36%
- Dry mouth25%
- Sleepiness25%
- Nausea22%
- Dizziness17%
- Constipation14%
- Weakness11%
- Trouble sleeping11%
- Lightheadedness10%
- Indigestion9%
- Blurry vision9%
- Infection8%
- Diarrhea8%
- Confusion7%
- Blind spots in vision7%
- Sore throat6%
- Increased appetite5%
- Changes in blood pressure4%
- Memory problems4%
- Tingling or prickling sensation4%
- Flushing4%
- Flu3%
- Swelling in the arms and legs3%
- Abnormal dreams3%
- Decreased concentration3%
- Increased cough3%
- Chills2%
- Fever2%
- Low blood pressure2%
- Itching2%
- Skin rashes2%
- Nausea and vomiting2%
- Trouble controlling movements2%
- Coordination problems2%
- Slowing of movement or speech2%
- Tremor2%
- Ringing in the ears2%
- Changes in taste2%
- Frequent urination2%
- Urinary tract infection2%
- Problems emptying bladder2%
- Vaginal discharge, itching, and pain2%
Risks and risk factors
- Suicidal thoughts or behavior
- Age 24 years or younger
- Serotonin syndrome
- Taking tricyclic antidepressants, lithium, tramadol, fentanyl, amphetamines, certain headache medications (triptans), St. John's Wort
- Withdrawal
- Stopping Cymbalta (duloxetine) abruptly
- Increased bleeding
- Taking other blood-thinning drugs (including aspirin, NSAIDs such as Advil, warfarin)
- Changes in blood pressure and risk of falls
- Elderly patients
- History of gait disturbances
- Taking more than 60 mg of Cymbalta (duloxetine) daily
- Taking other medicines that lower blood pressure
- History of high blood pressure
- Bipolar disorder
- History of bipolar disorder
- At risk for bipolar disorder
- Higher risk of suicide
- People under age 24
- Liver failure
- Low blood pressure
- Taking medicine for high blood pressure
- Possible bipolar disorder
- Seizures
- History of seizures
- Lower heart rate
- History of heart attack or heart disease
- Medicines that slow the heartbeat