Compare Dantrium vs. Botox

Head-to-head comparisons of medication uses, side effects, ratings, and more.


Dantrium (dantrolene)

Prescription only
Relaxes your muscles.

Dantrium (dantrolene) effectively treats malignant hyperthermia (increased temperature and muscle contractions when receiving anesthesia) and is the only medicine used to treat the condition. Dantrium (dantrolene) is not a first-choice treatment for general muscle spasms because it can damage your liver.

Prevents headaches in people with chronic migraines and treats various other problems such as muscle spasms, wrinkles, and excessive sweating.

Botox (onabotulinumtoxinA) is a prescription medicine that's good at treating many conditions, but it has potentially dangerous side effects.

  • Dantrium (dantrolene) effectively treats malignant hyperthermia.
  • Can be used for muscle spasticity if other medications haven't worked.
  • Available as generic.
  • Botox (onabotulinumtoxinA) can prevent migraines before they even start.
  • Since Botox (onabotulinumtoxinA) only prevents migraines, you can continue to take other medicines to lower pain once a migraine has already started, unless your doctor has given you other instructions.
  • You may start to feel results in a few days to a few weeks, depending on what you're using it for.
  • Botox (onabotulinumtoxinA) isn’t a daily or weekly medication. Depending on your condition, you only need to take it every couple months.
  • Not a first-choice treatment for muscle spasms because it can cause liver damage.
  • Can cause dizziness, sleepiness, and sometimes severe diarrhea.
  • Needs routine blood tests since it can injure your liver.
  • Dose needs to be increased slowly to minimize side effects.
  • Only comes as an injection.
  • Botox (onabotulinumtoxinA) works by weakening your muscles, which can cause swallowing, speaking, or breathing problems. Tell your doctor if you already have these problems before injection. If you develop these problems after injection, call your doctor or go to the emergency room right away.
  • If you take Botox (onabotulinumtoxinA) for chronic migraines, it’s unknown if it’s safe or will work for adults who have 14 or fewer headache days each month.
Used for
  • Malignant hyperthermia
  • Chronic spasticity
  • Neuroleptic malignant syndrome
Dosage forms
  • Pill
  • Injection
  • Injection
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Side effects
The Dantrium (dantrolene) FDA package insert doesn’t have numbers about how common side effects are.
13possible side effects
  • Neck pain
  • Headache
  • Migraine
  • Drooping eyelids
  • Stiffness in bones, joints, muscles
  • Muscle weakness
  • Bronchitis
  • Muscle pain
  • Pain in bones, joints, muscles
  • Injection site pain
  • Facial paralysis
  • Muscle spasms
  • High blood pressure
See more detailed side effects
Risks and risk factors
  • Liver injury
    • Taking 800 mg or more Dantrium (dantrolene) per day
    • Women
    • Over 35 years old
    • Elderly
    • History of liver disease or dysfunction
  • Drowsiness and dizziness
    • Alcohol or recreational drug use
  • Sun sensitivity
  • Lung disease
    • COPD
    • Heart failure
See more detailed risks and warnings
  • Increased toxic effect
    • Child using Botox (onabotulinumtoxinA) for spasticity
    • Using Botox (onabotulinumtoxinA) for uncontrollable neck spasms
    • Adult using Botox (onabotulinumtoxinA) for spasticity
  • Lung damage
    • History of lung problems
  • Greater risk of side effects
    • History of neuromuscular disease
  • Urinary tract infection or urinary retention
    • History of multiple sclerosis
    • History of diabetes mellitus
See more detailed risks and warnings