Compare Dantrium vs. Detrol

Head-to-head comparisons of medication uses, side effects, ratings, and more.


Dantrium (dantrolene)

Prescription only

Detrol (tolterodine)

Prescription only
Relaxes your muscles.

Dantrium (dantrolene) effectively treats malignant hyperthermia (increased temperature and muscle contractions when receiving anesthesia) and is the only medicine used to treat the condition. Dantrium (dantrolene) is not a first-choice treatment for general muscle spasms because it can damage your liver.

Treats overactive bladder.

Detrol (tolterodine) is a good treatment for overactive bladder after exercises and other methods to control it haven't worked.

  • Dantrium (dantrolene) effectively treats malignant hyperthermia.
  • Can be used for muscle spasticity if other medications haven't worked.
  • Available as generic.
  • Detrol (tolterodine) is effective at treating overactive bladder by lowering the urge to urinate, and controlling urination.
  • The tablet is available as a generic in both extended and immediate release, so you can take it once or twice a day.
  • Not a first-choice treatment for muscle spasms because it can cause liver damage.
  • Can cause dizziness, sleepiness, and sometimes severe diarrhea.
  • Needs routine blood tests since it can injure your liver.
  • Dose needs to be increased slowly to minimize side effects.
  • Detrol (tolterodine) can cause drowsiness, dizziness and can increase your risk for falls.
  • Detrol (tolterodine) can cause severe dry mouth and eyes and constipation.
  • Generally not recommended if you are 65 or older.
  • Do not use if you have uncontrolled narrow-angle glaucoma.
Used for
  • Malignant hyperthermia
  • Chronic spasticity
  • Neuroleptic malignant syndrome
Dosage forms
  • Pill
  • Injection
  • Pill
  • Extended release
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Side effects
The Dantrium (dantrolene) FDA package insert doesn’t have numbers about how common side effects are.
10possible side effects
  • Dry mouth
  • Headache
  • Constipation
  • Stomach pain
  • Indigestion
  • Dry eyes
  • Sleepiness
  • Tiredness
  • Dizziness
  • Flu-like symptoms
See more detailed side effects
Risks and risk factors
  • Liver injury
    • Taking 800 mg or more Dantrium (dantrolene) per day
    • Women
    • Over 35 years old
    • Elderly
    • History of liver disease or dysfunction
  • Drowsiness and dizziness
    • Alcohol or recreational drug use
  • Sun sensitivity
  • Lung disease
    • COPD
    • Heart failure
See more detailed risks and warnings
  • Face, lips, neck or throat swelling
  • Dizziness and drowsiness
    • Taking with alcohol
    • Taking other medicines that make you less alert
    • People age 65 or older
  • Vision changes
    • Glaucoma
  • Trouble urinating & stomach problems
    • History of bladder problems
    • History of stomach or intestine problems
  • Heartbeat problems
    • History of heartbeat problems
    • Taking medicines to conrol heartbeat
  • Liver and Kidney problems
    • History of liver problems
    • History of Kidney problems
See more detailed risks and warnings