Compare delavirdine vs. Edurant

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Rescriptor (delavirdine)

Prescription only

Edurant (rilpivirine)

Prescription only
Treats HIV infection.

Rescriptor (delavirdine) is a good alternative, but it's not a first-choice medicine due to its 3 times a day dosing and is not as effective compared to other HIV medications.

Works with other medications to treat HIV infection.

Edurant (rilpivirine) is a good HIV drug that has to be used in combination with other HIV medications in patients who are new to treatment or are looking for alternatives to a current HIV regimen.

Upsides
  • People with mild to moderate kidney damage can use this medication.
  • Can take with or without food.
  • Can crush pill form and mix with water if you have trouble swallowing.
  • Generally well tolerated.
  • Taken only once daily.
  • Edurant (rilpivirine) is available in other combination tablets.
  • Can be used in patients with mild or moderate kidney damage.
Downsides
  • Doesn't prevent disease transmission, so you must use a condom during sex.
  • Must take at least 1 hour before or after antacids or didanosine.
  • There are multiple drug interactions with Rescriptor (delavirdine), so you must talk to your doctor before starting any new medications.
  • Have to take 3 times a day, so may not be convenient for some people.
  • Cannot use as part of an initial HIV regimen and only use in combination with other HIV medications.
  • Must be taken in combination with other HIV drugs to treat HIV. Cannot be taken alone as treatment.
  • Must be taken with a meal.
  • Cannot be taken with proton pump inhibitors (PPI) like Prilosec or Prevacid. If you need to take an acid reducer, try an antacid like calcium carbonate either 2 hours before or 4 hours after Edurant (rilpivirine). Drugs like Pepcid or Zantac (H2RAs) may also be an option, but these should be taken 12 hours before or 4 hours after Edurant (rilpivirine).
  • Not recommended for patients who have a significantly high level of viral cells or have a very low level of immune cells.
  • Not recommended for children under 12 years old.
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Dosage forms
  • Pill
  • Pill
Price
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Reviews
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Side effects
1possible side effects
  • Skin rash
    35%
See more detailed side effects
7possible side effects
  • Depressive disorders
    5%
  • Headache
    3%
  • Insomnia
    3%
  • Rash
    3%
  • Abdominal pain
    2%
  • Fatigue
    2%
  • Abnormal dreams
    2%
See more detailed side effects
Risks and risk factors
  • Drug interactions
    • Concurrent use of multiple medications
  • Immune reconstitution syndrome
    • HIV
    • Exposure to other infections
    • Start of a new HIV medication
    • Change in HIV therapy
  • Fat redistribution
    • HIV treatment
  • Skin rash
    • History of severe skin reactions
  • Resistance/Cross-resistance
See more detailed risks and warnings
  • Mood and behavior changes
    • History of mental health problems
  • Immune reconstitution syndrome
    • Exposure to other infections
    • Start of a new HIV medication
    • Change in HIV therapy
  • Fat Redistribution
  • Allergic reactions
    • Prior severe allergic reaction to Edurant (rilpivirine)
  • Liver damage
    • History of liver damage
    • Hepatitis B or C
  • Heart rhythm problems
    • Use with other QT prolonging drugs
    • History of heart disease
    • High doses of Edurant
See more detailed risks and warnings