Compare Delzicol vs. Sulfasalazine

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Delzicol (mesalamine)

Prescription only
Treats ulcerative colitis and helps prevent flares.

Delzicol (mesalamine) effectively reduces symptoms of a flare for mild to moderate ulcerative colitis in both children and adults, but can cause burping and stomach discomfort.

Reduces inflammation.

Azulfidine (Sulfasalazine) is used to treat moderate to severe inflammatory bowel conditions. It's also used with other medicines to treat rheumatoid arthritis.

Upsides
  • Delzicol (mesalamine) effectively treats ulcerative colitis flares.
  • This drug is often used as the first-choice treatment in adults and children.
  • If you have trouble swallowing the drug whole, the pill can be opened and you can swallow the tablets inside.
  • Can be used in children 5 years and older.
  • Can slow down the progression of your rheumatoid arthritis.
  • Helps control your stomach problems if you're taking it for ulcerative colitis.
Downsides
  • Treatment dosage must be taken 3 times a day for a total of 6 weeks.
  • Can take a few weeks before you start to feel the effects.
  • Delzicol (mesalamine) is not available as a cheaper, generic form.
  • Combination therapy with oral and rectal forms may be needed for some people.
  • This form of mesalamine isn't used for maintenance, only to help reduce flare symptoms.
  • Requires constant lab monitoring, at least every other week when you first start using it.
  • Not a good option if you have kidney or liver disease.
  • If you're allergic to sulfa drugs or aspirin, you can't take Azulfidine (Sulfasalazine).
  • Can interfere with lab test results, so let your doctor know if you're taking this drug.
  • Interacts with a lot of different drugs and can also cause many side effects.
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Used for
Dosage forms
  • Delayed-release pill
  • Pill
  • Extended release
Price
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Reviews
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Side effects
9possible side effects
  • Burping
    26%
  • Abdominal pain
    21%
  • Constipation
    11%
  • Dizziness
    9%
  • Runny nose
    8%
  • Back pain
    6%
  • Rash
    6%
  • Upset stomach
    4%
  • Flu syndrome
    4%
See more detailed side effects
8possible side effects
  • Nausea
    19%
  • Stomach problems
    13%
  • Rash
    13%
  • Headache
    9%
  • Stomach pain
    8%
  • Vomiting
    8%
  • Fever
    5%
  • Dizziness
    4%
See more detailed side effects
Risks and risk factors
  • Kidney problems
    • Preexisting kidney problems
    • Taking medications toxic to the kidney
  • Liver problems
    • Preexisting liver problems
    • Taking other medications toxic to the liver
  • Serious allergic reactions
    • Sulfasalazine reaction
  • Abnormal response to Delzicol (mesalamine)
See more detailed risks and warnings
  • Kidney, liver, or blood problems
  • Serious skin reactions
  • Serious allergic reactions
  • Serious infections
  • Drug interactions
See more detailed risks and warnings