Compare Depakote vs. Dantrium

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Depakote (divalproex)

Prescription only

Dantrium (dantrolene)

Prescription only
Treats and prevents seizures, and stabilizes mood.

Depakote (divalproex) is good for long-term prevention of seizures, manic episodes in bipolar disorder, and migraines.

3.3/ 5 average rating with 97 reviewsforDepakote
Relaxes your muscles.

Dantrium (dantrolene) effectively treats malignant hyperthermia (increased temperature and muscle contractions when receiving anesthesia) and is the only medicine used to treat the condition. Dantrium (dantrolene) is not a first-choice treatment for general muscle spasms because it can damage your liver.

  • Lowers the frequency of seizures, especially for people with absence seizures or complex partial seizures.
  • Depakote (divalproex) is a first-line treatment to stabilize mood for people with bipolar disorder.
  • Depakote (divalproex) is helpful for preventing frequent migraines.
  • The sprinkle pill can be swallowed whole or can be opened up and mixed with applesauce if you have a hard time swallowing.
  • Depakote (divalproex) is available as a generic.
  • Dantrium (dantrolene) effectively treats malignant hyperthermia.
  • Can be used for muscle spasticity if other medications haven't worked.
  • Available as generic.
  • It can take 3 to 4 weeks before you feel the full effects of Depakote (divalproex).
  • Depakote (divalproex) is not a good medication for people with liver problems.
  • Requires regular blood tests to see how the medication is affecting your body.
  • Depakote (divalproex) can make you bleed more easily.
  • Not a first-choice treatment for muscle spasms because it can cause liver damage.
  • Can cause dizziness, sleepiness, and sometimes severe diarrhea.
  • Needs routine blood tests since it can injure your liver.
  • Dose needs to be increased slowly to minimize side effects.
Used for
  • Malignant hyperthermia
  • Chronic spasticity
  • Neuroleptic malignant syndrome
Dosage forms
  • Pill
  • Extended release pill
  • Delayed release pill
  • Pill
  • Injection
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97 reviews so far
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Side effects
9possible side effects
  • Nausea
  • Sleepiness
  • Dizziness
  • Vomiting
  • Accidental injury
  • Feeling weak
  • Abdominal pain
  • Upset stomach
  • Rash
See more detailed side effects
The Dantrium (dantrolene) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Harm to fetus
  • Liver damage
    • Children under age 2
    • History of metabolic disorders
    • Severe seizure disorder
    • Brain disease
    • History of liver problems
  • Pancreas problems
  • Suicidal thoughts or behavior
    • History of depression
  • Increased bleeding
  • Mental changes
    • History of metabolic disorders
    • People also taking Topamax
See more detailed risks and warnings
  • Liver injury
    • Taking 800 mg or more Dantrium (dantrolene) per day
    • Women
    • Over 35 years old
    • Elderly
    • History of liver disease or dysfunction
  • Drowsiness and dizziness
    • Alcohol or recreational drug use
  • Sun sensitivity
  • Lung disease
    • COPD
    • Heart failure
See more detailed risks and warnings