Compare Depakote vs. Keppra

Head-to-head comparisons of medication uses, side effects, ratings, and more.

ADVERTISEMENT

Depakote (divalproex)

Prescription only

Keppra (levetiracetam)

Prescription only
Treats and prevents seizures, and stabilizes mood.

Depakote (divalproex) is good for long-term prevention of seizures, manic episodes in bipolar disorder, and migraines.

3.3/ 5 average rating with 97 reviewsforDepakote
Prevents seizures.

Keppra (levetiracetam) is effective for preventing seizures in people with epilepsy and has fewer drug interactions than its alternatives.

4.5/ 5 average rating with 21 reviewsforKeppra
Upsides
  • Lowers the frequency of seizures, especially for people with absence seizures or complex partial seizures.
  • Depakote (divalproex) is a first-line treatment to stabilize mood for people with bipolar disorder.
  • Depakote (divalproex) is helpful for preventing frequent migraines.
  • The sprinkle pill can be swallowed whole or can be opened up and mixed with applesauce if you have a hard time swallowing.
  • Depakote (divalproex) is available as a generic.
  • Keppra (levetiracetam) is effective at lowering the frequency of various types of seizures.
  • Keppra (levetiracetam) is available in liquid form or dissolving tablets if you have trouble swallowing pills.
  • Compared to other seizure medications, Keppra (levetiracetam) has fewer side effects and drug interactions, and usually does not require monitoring blood levels.
Downsides
  • It can take 3 to 4 weeks before you feel the full effects of Depakote (divalproex).
  • Depakote (divalproex) is not a good medication for people with liver problems.
  • Requires regular blood tests to see how the medication is affecting your body.
  • Depakote (divalproex) can make you bleed more easily.
  • Must be taken on time so that there are consistent levels of the drug in your body.
  • Keppra (levetiracetam) may not be the best drug to take if you have a history of mood problems, such as depression or bipolar disorder.
  • If you have kidney problems, your dose will need to be adjusted and your doctor will check your kidney function regularly.
  • Due to its effects on your balance, Keppra (levetiracetam) may not be appropriate for the elderly.
ADVERTISEMENT
Used for
Dosage forms
  • Pill
  • Extended release pill
  • Delayed release pill
  • Pill
  • Extended release
  • Liquid
  • Oral disintegrating tablet
Price
Want to save even more money?
Sign up now for a 30-day trial and save up to 95% at CVS, Kroger, Albertsons, and other pharmacies.
Learn more
Reviews
97 reviews so far
46%
saidit'sworth it
40%
saiditworked well
27%
saidit'sa big hassle

Have you used Depakote (divalproex)?

Leave a review
21 reviews so far
33%
saidit'sworth it
81%
saiditworked well
33%
saidit'sa big hassle

Have you used Keppra (levetiracetam)?

Leave a review
Side effects
9possible side effects
  • Nausea
    22%
  • Sleepiness
    19%
  • Dizziness
    12%
  • Vomiting
    12%
  • Accidental injury
    11%
  • Feeling weak
    10%
  • Abdominal pain
    9%
  • Upset stomach
    9%
  • Rash
    6%
See more detailed side effects
13possible side effects
  • Drowsiness
    12%
  • Neck pain
    8%
  • Inflammation of the back of throat
    7%
  • Feeling off balance
    5%
  • Flu symptoms
    5%
  • Depression
    5%
  • Anxiety
    3%
  • Depressed mood
    2%
  • Double vision
    2%
  • Excessive sleepiness
    2%
  • Difficulty sleeping
    2%
  • Irritability
    2%
  • Nervousness
    2%
See more detailed side effects
Risks and risk factors
  • Harm to fetus
  • Liver damage
    • Children under age 2
    • History of metabolic disorders
    • Severe seizure disorder
    • Brain disease
    • History of liver problems
  • Pancreas problems
  • Suicidal thoughts or behavior
    • History of depression
  • Increased bleeding
  • Mental changes
    • History of metabolic disorders
    • People also taking Topamax
See more detailed risks and warnings
  • Life-threatening skin reactions
  • Suicidal thoughts or behavior
  • Driving impairment
    • Taking with alcohol
    • Taking other medicines that make you less alert
  • Blood disorders
  • Withdrawal seizures
    • Stopping Keppra (levetiracetam) suddenly
  • Psychiatric side effects
    • History of psychiatric problems
    • Ages less than 18
See more detailed risks and warnings