Compare Depakote vs. Latuda

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Depakote (divalproex)

Prescription only

Latuda (lurasidone)

Prescription only
Treats and prevents seizures, and stabilizes mood.

Depakote (divalproex) is good for long-term prevention of seizures, manic episodes in bipolar disorder, and migraines.

3.3/ 5 average rating with 97 reviewsforDepakote
Helps control your thoughts and mood.

Latuda (lurasidone) is good for treating schizophrenia and depression related to bipolar disorder, but can cause sleepiness and movement disorders that can affect your ability to stay alert.

3.8/ 5 average rating with 61 reviewsforLatuda
Upsides
  • Lowers the frequency of seizures, especially for people with absence seizures or complex partial seizures.
  • Depakote (divalproex) is a first-line treatment to stabilize mood for people with bipolar disorder.
  • Depakote (divalproex) is helpful for preventing frequent migraines.
  • The sprinkle pill can be swallowed whole or can be opened up and mixed with applesauce if you have a hard time swallowing.
  • Depakote (divalproex) is available as a generic.
  • Has been shown in clinical studies to help people experience improvement in their thoughts and mood.
  • Can be taken alone or with other medications that manage your mood.
  • Compared to other antipsychotic medicines, Latuda (lurasidone) has a lower risk of causing weight gain, high cholesterol, high blood sugar, and heart rhythm changes.
Downsides
  • It can take 3 to 4 weeks before you feel the full effects of Depakote (divalproex).
  • Depakote (divalproex) is not a good medication for people with liver problems.
  • Requires regular blood tests to see how the medication is affecting your body.
  • Depakote (divalproex) can make you bleed more easily.
  • It may take several weeks before you feel the full effects of Latuda (lurasidone).
  • You may get more side effects if you're taking certain antifungal and heart medicines.
  • Can cause you to be more sensitive to heat and make it harder for your body to cool off.
  • Need to avoid drinking alcohol while taking Latuda (lurasidone).
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Used for
Dosage forms
  • Pill
  • Extended release pill
  • Delayed release pill
  • Pill
Price
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Reviews
97 reviews so far
46%
saidit'sworth it
40%
saiditworked well
27%
saidit'sa big hassle

Have you used Depakote (divalproex)?

Leave a review
61 reviews so far
61%
saidit'sworth it
61%
saiditworked well
25%
saidit'sa big hassle

Have you used Latuda (lurasidone)?

Leave a review
Side effects
9possible side effects
  • Nausea
    22%
  • Sleepiness
    19%
  • Dizziness
    12%
  • Vomiting
    12%
  • Accidental injury
    11%
  • Feeling weak
    10%
  • Abdominal pain
    9%
  • Upset stomach
    9%
  • Rash
    6%
See more detailed side effects
12possible side effects
  • Nausea
    14%
  • Sleepiness
    11%
  • Restlessness
    9%
  • Movement disorder
    7%
  • Dry mouth
    5%
  • Vomiting
    4%
  • Diarrhea
    4%
  • Common cold
    4%
  • Anxiety
    4%
  • Flu
    2%
  • Urinary tract infection
    2%
  • Back pain
    2%
See more detailed side effects
Risks and risk factors
  • Harm to fetus
  • Liver damage
    • Children under age 2
    • History of metabolic disorders
    • Severe seizure disorder
    • Brain disease
    • History of liver problems
  • Pancreas problems
  • Suicidal thoughts or behavior
    • History of depression
  • Increased bleeding
  • Mental changes
    • History of metabolic disorders
    • People also taking Topamax
See more detailed risks and warnings
  • Increased risk of death
    • Elderly patients with dementia
  • Suicidal thoughts or behavior
  • Abnormal and involuntary muscle movements
    • Taking Latuda (lurasidone) in higher doses or for a long time
    • Elderly
    • Female
  • Low blood pressure
    • Dehydration
    • Taking blood pressure medications
  • Sedation and driving impairment
    • Taking with alcohol
    • Taking other medicines that make you less alert
  • Low white blood cells
See more detailed risks and warnings