Compare Depakote vs. lidocaine

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Treats and prevents seizures, and stabilizes mood.

Depakote (divalproex) is good for long-term prevention of seizures, manic episodes in bipolar disorder, and migraines.

3.3/ 5 average rating with 97 reviewsforDepakote
Treats nerve pain.

Lidoderm (lidocaine) works well to treat nerve pain that is localized to a small area, but its topical application may cause minor skin irritation.

4.2/ 5 average rating with 18 reviewsforlidocaine
Upsides
  • Lowers the frequency of seizures, especially for people with absence seizures or complex partial seizures.
  • Depakote (divalproex) is a first-line treatment to stabilize mood for people with bipolar disorder.
  • Depakote (divalproex) is helpful for preventing frequent migraines.
  • The sprinkle pill can be swallowed whole or can be opened up and mixed with applesauce if you have a hard time swallowing.
  • Depakote (divalproex) is available as a generic.
  • Minimal side-effects compared to other pain relievers since it works locally at the site of application.
  • Won't hurt your kidneys or liver unlike other pain relievers.
  • Available in many different topical formulations to fit your needs.
Downsides
  • It can take 3 to 4 weeks before you feel the full effects of Depakote (divalproex).
  • Depakote (divalproex) is not a good medication for people with liver problems.
  • Requires regular blood tests to see how the medication is affecting your body.
  • Depakote (divalproex) can make you bleed more easily.
  • Application may cause minor stinging or burning skin irritation.
  • Used patches requires proper medication disposal since it still contain enough medicine to be dangerous to children and pets.
  • Not a good choice if you've had allergic reactions to numbing medications (local anesthetics) or have a history of irregular heartbeats.
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Used for
Dosage forms
  • Pill
  • Extended release pill
  • Delayed release pill
  • Cream
  • Gel
  • Ointment
  • Jelly
  • Spray
  • Patch
  • Lotion
  • Topical solution
Price
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Reviews
97 reviews so far
46%
saidit'sworth it
40%
saiditworked well
27%
saidit'sa big hassle

Have you used Depakote (divalproex)?

Leave a review
18 reviews so far
67%
saidit'sworth it
72%
saiditworked well
22%
saidit'sa big hassle

Have you used Lidoderm (lidocaine)?

Leave a review
Side effects
9possible side effects
  • Nausea
    22%
  • Sleepiness
    19%
  • Dizziness
    12%
  • Vomiting
    12%
  • Accidental injury
    11%
  • Feeling weak
    10%
  • Abdominal pain
    9%
  • Upset stomach
    9%
  • Rash
    6%
See more detailed side effects
The Lidoderm (lidocaine) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Harm to fetus
  • Liver damage
    • Children under age 2
    • History of metabolic disorders
    • Severe seizure disorder
    • Brain disease
    • History of liver problems
  • Pancreas problems
  • Suicidal thoughts or behavior
    • History of depression
  • Increased bleeding
  • Mental changes
    • History of metabolic disorders
    • People also taking Topamax
See more detailed risks and warnings
  • Overdose
    • Use of heating pad on skin
    • Applying patch to red, irritated or broken skin
    • Leaving patch on for more than 12 hours
    • Using patch on a very large area
    • Older age
    • Smaller patients
    • Liver disease
  • Accidental poisoning
    • Not disposing of Lidoderm (lidocaine) correctly
  • Eye irritation
    • Not washing hands after touching or applying Lidoderm (lidocaine)
  • Skin reactions
    • Applying Lidoderm (lidocaine) to warm skin
    • Covering patch with wrap or heating pad
  • Heart problems
    • History of heart problems
    • Using Lidoderm (lidocaine) with medications to treat irregular heartbeat
See more detailed risks and warnings