Compare Depakote vs. Oxybutynin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Depakote (divalproex)

Prescription only

Oxytrol (Oxybutynin)

Prescription only
Treats and prevents seizures, and stabilizes mood.

Depakote (divalproex) is good for long-term prevention of seizures, manic episodes in bipolar disorder, and migraines.

3.3/ 5 average rating with 97 reviewsforDepakote
Treats an overactive bladder.

Oxytrol (Oxybutynin) is a good treatment for overactive bladder, but watch out for side effects such as dry mouth and constipation.

Upsides
  • Lowers the frequency of seizures, especially for people with absence seizures or complex partial seizures.
  • Depakote (divalproex) is a first-line treatment to stabilize mood for people with bipolar disorder.
  • Depakote (divalproex) is helpful for preventing frequent migraines.
  • The sprinkle pill can be swallowed whole or can be opened up and mixed with applesauce if you have a hard time swallowing.
  • Depakote (divalproex) is available as a generic.
  • Oxytrol (Oxybutynin) is effective at treating overactive bladder by lowering the urge to urinate, and helping to better control urination.
  • Available in multiple forms: a patch, gel, extended-release tablet, and tablet.
  • The gel form of Oxytrol (Oxybutynin) is available over the counter without a prescription.
  • Oxytrol (Oxybutynin) patch and gel have fewer side effects than taking the tablet.
  • The tablet is available as a generic.
Downsides
  • It can take 3 to 4 weeks before you feel the full effects of Depakote (divalproex).
  • Depakote (divalproex) is not a good medication for people with liver problems.
  • Requires regular blood tests to see how the medication is affecting your body.
  • Depakote (divalproex) can make you bleed more easily.
  • Generally not recommended to use in people ages 65 and older since it can cause drowsiness and increase the risk of falls.
  • Can’t be used if you have uncontrolled narrow-angle glaucoma.
  • Not recommended if you have ulcerative colitis or certain other stomach problems since Oxytrol (Oxybutynin) can slow stomach emptying.
  • Not the best choice if you have GERD (acid reflux), since Oxytrol (Oxybutynin) can irritate your throat and make the acid reflux worse.
  • Has more side effects than newer medicines that treat overactive bladder.
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Used for
Dosage forms
  • Pill
  • Extended release pill
  • Delayed release pill
  • Pill
  • Extended release
  • Liquid
  • Cream, gel, or ointment
  • Patch
Price
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Reviews
97 reviews so far
46%
saidit'sworth it
40%
saiditworked well
27%
saidit'sa big hassle

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Side effects
9possible side effects
  • Nausea
    22%
  • Sleepiness
    19%
  • Dizziness
    12%
  • Vomiting
    12%
  • Accidental injury
    11%
  • Feeling weak
    10%
  • Abdominal pain
    9%
  • Upset stomach
    9%
  • Rash
    6%
See more detailed side effects
The Oxytrol (Oxybutynin) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Harm to fetus
  • Liver damage
    • Children under age 2
    • History of metabolic disorders
    • Severe seizure disorder
    • Brain disease
    • History of liver problems
  • Pancreas problems
  • Suicidal thoughts or behavior
    • History of depression
  • Increased bleeding
  • Mental changes
    • History of metabolic disorders
    • People also taking Topamax
See more detailed risks and warnings
  • Unusual tongue swelling
  • Driving impairment
    • Taking with alcohol
    • Taking other medicines that make you less alert
  • Heat exhaustion
    • Outside in hot weather
    • Dehydrated
    • Exercising
See more detailed risks and warnings