Compare Depakote vs. oxybutynin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Depakote (divalproex)

Prescription only

Ditropan (oxybutynin)

Prescription or OTC
Treats and prevents seizures, and stabilizes mood.

Depakote (divalproex) is good for long-term prevention of seizures, manic episodes in bipolar disorder, and migraines.

3.3/ 5 average rating with 97 reviewsforDepakote
Treats overactive bladder.

Ditropan (oxybutynin) is good treatment for overactive bladder, but has more side-effects like dry mouth and constipation than other medicines that work similarly.

Upsides
  • Lowers the frequency of seizures, especially for people with absence seizures or complex partial seizures.
  • Depakote (divalproex) is a first-line treatment to stabilize mood for people with bipolar disorder.
  • Depakote (divalproex) is helpful for preventing frequent migraines.
  • The sprinkle pill can be swallowed whole or can be opened up and mixed with applesauce if you have a hard time swallowing.
  • Depakote (divalproex) is available as a generic.
  • Available in several different formulations (pill, liquid, gel, patch) that help fit individual preferences.
  • The pill form is available in a cheap, generic version.
  • Works just as well as newer medications on the market in managing symptoms of an overactive bladder.
  • The patch form causes less side effects than the other forms of Ditropan (oxybutynin).
Downsides
  • It can take 3 to 4 weeks before you feel the full effects of Depakote (divalproex).
  • Depakote (divalproex) is not a good medication for people with liver problems.
  • Requires regular blood tests to see how the medication is affecting your body.
  • Depakote (divalproex) can make you bleed more easily.
  • Raises the risk of falls, especially in older people.
  • Ditropan (oxybutynin) may not be a good treatment option if you also have narrow-angle glaucoma.
  • Causes more side effects like dry mouth than newer medications used for treating overactive bladder.
  • Older people who use Ditropan (oxybutynin) are at higher risk of experiencing memory problems as well as side effects such as confusion and blurry vision.
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Used for
Dosage forms
  • Pill
  • Extended release pill
  • Delayed release pill
  • Pill
  • Extended-release pill
  • Liquid
  • Patch
  • Gel
Price
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Reviews
97 reviews so far
46%
saidit'sworth it
40%
saiditworked well
27%
saidit'sa big hassle

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Side effects
9possible side effects
  • Nausea
    22%
  • Sleepiness
    19%
  • Dizziness
    12%
  • Vomiting
    12%
  • Accidental injury
    11%
  • Feeling weak
    10%
  • Abdominal pain
    9%
  • Upset stomach
    9%
  • Rash
    6%
See more detailed side effects
17possible side effects
  • Dry mouth
    35%
  • Constipation
    9%
  • Headache
    8%
  • Diarrhea
    8%
  • Insomnia
    6%
  • Drowsiness
    6%
  • Dizziness
    5%
  • Upset stomach
    5%
  • Nausea
    5%
  • Blurry vision
    4%
  • Dry eyes
    3%
  • Fatigue
    3%
  • Taste changes
    2%
  • Cough
    2%
  • Dry throat
    2%
  • Dry nose
    2%
  • Inability to urinate
    2%
See more detailed side effects
Risks and risk factors
  • Harm to fetus
  • Liver damage
    • Children under age 2
    • History of metabolic disorders
    • Severe seizure disorder
    • Brain disease
    • History of liver problems
  • Pancreas problems
  • Suicidal thoughts or behavior
    • History of depression
  • Increased bleeding
  • Mental changes
    • History of metabolic disorders
    • People also taking Topamax
See more detailed risks and warnings
  • Drowsiness and confusion
    • Taking with alcohol
    • Taking other medicines that make you less alert
  • Vision changes
    • Glaucoma
  • Trouble urinating
    • History of bladder problems
    • History of problems with your intestine
    • Taking more than one medicine for overactive bladder or taking allergy medicines
  • More side effects
    • Taking high doses
    • Age over 65 years
  • Heat exhaustion
    • Outside in hot weather
    • Dehydrated
    • Exercising
See more detailed risks and warnings