Compare Depakote vs. Sanctura

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Depakote (divalproex)

Prescription only

Sanctura (trospium)

Prescription only
Treats and prevents seizures, and stabilizes mood.

Depakote (divalproex) is good for long-term prevention of seizures, manic episodes in bipolar disorder, and migraines.

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3.3/ 5 average rating with 97 reviewsforDepakote
Treats overactive bladder.

Sanctura (trospium) is a good treatment for overactive bladder after exercises when other methods to control it haven't worked.

Upsides
  • Lowers the frequency of seizures, especially for people with absence seizures or complex partial seizures.
  • Depakote (divalproex) is a first-line treatment to stabilize mood for people with bipolar disorder.
  • Depakote (divalproex) is helpful for preventing frequent migraines.
  • The sprinkle pill can be swallowed whole or can be opened up and mixed with applesauce if you have a hard time swallowing.
  • Depakote (divalproex) is available as a generic.
  • Sanctura (trospium) is effective at treating overactive bladder.
  • Sanctura (trospium) may be a better choice if you have liver problems.
  • Sanctura (trospium) is available as a generic.
Downsides
  • It can take 3 to 4 weeks before you feel the full effects of Depakote (divalproex).
  • Depakote (divalproex) is not a good medication for people with liver problems.
  • Requires regular blood tests to see how the medication is affecting your body.
  • Depakote (divalproex) can make you bleed more easily.
  • You have to take Sanctura (trospium) on an empty stomach.
  • You may need to take Sanctura (trospium) twice a day.
  • Sanctura (trospium) can cause drowsiness, dizziness, and increase your risk for falls.
  • Generally not recommended if you older than 65.
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Used for
Dosage forms
  • Pill
  • Extended release pill
  • Delayed release pill
  • Pill
  • Extended release
Price
Lowest price
$29.62
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Lowest price
$64.20
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Reviews
97 reviews so far
46%
saidit'sworth it
40%
saiditworked well
27%
saidit'sa big hassle

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Side effects
9possible side effects
  • Nausea
    22%
  • Sleepiness
    19%
  • Dizziness
    12%
  • Vomiting
    12%
  • Accidental injury
    11%
  • Feeling weak
    10%
  • Abdominal pain
    9%
  • Upset stomach
    9%
  • Rash
    6%
See more detailed side effects
4possible side effects
  • Dry mouth
    11%
  • Constipation
    9%
  • Dry eyes
    2%
  • Gas
    2%
See more detailed side effects
Risks and risk factors
  • Harm to fetus
  • Liver damage
    • Children under age 2
    • History of metabolic disorders
    • Severe seizure disorder
    • Brain disease
    • History of liver problems
  • Pancreas problems
  • Suicidal thoughts or behavior
    • History of depression
  • Increased bleeding
  • Mental changes
    • History of metabolic disorders
    • People also taking Topamax
See more detailed risks and warnings
  • Facial swelling & breathing problems
  • Difficulty concentrating
    • Taking with alcohol
    • Taking other medicines that make you less alert
    • People age 65 or older
  • Vision changes
    • Glaucoma
  • Urinary retention
    • Bladder outflow obstruction
  • Increased side effects
    • History of kidney problems
    • People age 65 or older
  • Heat exhaustion
    • Outside in hot weather
    • Dehydrated
    • Exercising
    • People age 65 and older
See more detailed risks and warnings
Learn more about Depakote (divalproex)
Learn more about Sanctura (trospium)