Compare Depakote vs. Sanctura

Head-to-head comparisons of medication uses, side effects, ratings, and more.


Depakote (divalproex)

Prescription only

Sanctura (trospium)

Prescription only
Treats and prevents seizures, and stabilizes mood.

Depakote (divalproex) is good for long-term prevention of seizures, manic episodes in bipolar disorder, and migraines.

3.3/ 5 average rating with 97 reviewsforDepakote
Treats overactive bladder.

Sanctura (trospium) is a good treatment for overactive bladder after exercises when other methods to control it haven't worked.

  • Lowers the frequency of seizures, especially for people with absence seizures or complex partial seizures.
  • Depakote (divalproex) is a first-line treatment to stabilize mood for people with bipolar disorder.
  • Depakote (divalproex) is helpful for preventing frequent migraines.
  • The sprinkle pill can be swallowed whole or can be opened up and mixed with applesauce if you have a hard time swallowing.
  • Depakote (divalproex) is available as a generic.
  • Sanctura (trospium) is effective at treating overactive bladder.
  • Sanctura (trospium) may be a better choice if you have liver problems.
  • Sanctura (trospium) is available as a generic.
  • It can take 3 to 4 weeks before you feel the full effects of Depakote (divalproex).
  • Depakote (divalproex) is not a good medication for people with liver problems.
  • Requires regular blood tests to see how the medication is affecting your body.
  • Depakote (divalproex) can make you bleed more easily.
  • You have to take Sanctura (trospium) on an empty stomach.
  • You may need to take Sanctura (trospium) twice a day.
  • Sanctura (trospium) can cause drowsiness, dizziness, and increase your risk for falls.
  • Generally not recommended if you older than 65.
Used for
Dosage forms
  • Pill
  • Extended release pill
  • Delayed release pill
  • Pill
  • Extended release
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97 reviews so far
saidit'sworth it
saiditworked well
saidit'sa big hassle

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Side effects
9possible side effects
  • Nausea
  • Sleepiness
  • Dizziness
  • Vomiting
  • Accidental injury
  • Feeling weak
  • Abdominal pain
  • Upset stomach
  • Rash
See more detailed side effects
4possible side effects
  • Dry mouth
  • Constipation
  • Dry eyes
  • Gas
See more detailed side effects
Risks and risk factors
  • Harm to fetus
  • Liver damage
    • Children under age 2
    • History of metabolic disorders
    • Severe seizure disorder
    • Brain disease
    • History of liver problems
  • Pancreas problems
  • Suicidal thoughts or behavior
    • History of depression
  • Increased bleeding
  • Mental changes
    • History of metabolic disorders
    • People also taking Topamax
See more detailed risks and warnings
  • Facial swelling & breathing problems
  • Difficulty concentrating
    • Taking with alcohol
    • Taking other medicines that make you less alert
    • People age 65 or older
  • Vision changes
    • Glaucoma
  • Urinary retention
    • Bladder outflow obstruction
  • Increased side effects
    • History of kidney problems
    • People age 65 or older
  • Heat exhaustion
    • Outside in hot weather
    • Dehydrated
    • Exercising
    • People age 65 and older
See more detailed risks and warnings