Compare Depo-Estradiol vs. Divigel
Head-to-head comparisons of medication uses, side effects, ratings, and more.
Treats low estrogen and relieves menopause symptoms.
Depo-Estradiol (estradiol cypionate injection) is a good once-a-month option for treating menopause symptoms and low estrogen, as long as you're comfortable with needles.
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3.2/ 5 average rating with 109 reviewsforDepo-Estradiol
Relieves hot flashes due to menopause.
Divigel (Estradiol gel) is an easy to use medicine that comes in 3 different strengths. It uses lower doses of estrogen than other hormone replacements.
Upsides
- You only need an injection once a month, which can be less of a hassle than pills, patches, creams, and gels.
- Your doctor can show you how to inject yourself so you can do it on your own at home.
- Replenishes estrogen to your whole body and relieves multiple symptoms.
- Less side effects since lower amounts of estrogen is used compared to the pills.
- Replaces estrogen to your whole body and relieves multiple symptoms due to low estrogen, like hot flashes and vaginal dryness.
- Good for people who don't want to or can't take daily pills.
- Can take the easy to use, pre-measured packets anywhere.
- Divigel (Estradiol gel) has fewer side effects than pills since there are lower amounts of estrogen in gels.
- In studies, many women on the lowest dose started to feel better about a month after starting the medicine. People using the highest doses felt better in just 2 weeks.
Downsides
- Requires injection with a needle, which can be difficult for some people.
- Increases your risk of endometrial and breast cancer.
- If you have an intact uterus, you have to use Depo-Estradiol (estradiol cypionate injection) with another hormone called progestin to lower your risk of uterine cancer.
- Can't be used in people with liver problems.
- Can be expensive since it's only available as a brand name product.
- Increases your risk of endometrial and breast cancer.
- If you have your uterus, you have to use Divigel (Estradiol gel) with another hormone called progestin to lower your risk of uterine cancer.
- Can't be used in people with liver problems.
- It's possible to expose other people to the estrogen before it's absorbed by your skin.
- Can be expensive since it's only available as a brand name product.
Used for
- Hot flashes
- Low estrogen
Dosage forms
- Injection
- Gel
Price
Lowest price
$112.56
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$131.33
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Reviews
109 reviews so far
40%
saidit'sworth it
28%
saiditworked well
18%
saidit'sa big hassle
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Side effects
The Depo-Estradiol (estradiol cypionate injection) FDA package insert doesn’t have numbers about how common side effects are.
5possible side effects
- Breast pain6%
- Unusual vaginal bleeding6%
- Common cold4%
- Lung infection2%
- Yeast infection2%
Risks and risk factors
- Endometrial cancer
- Taking estrogen replacement for more than one year
- Breast cancer
- Personal or family history of breast cancer
- Using estrogen for more than one year
- Increased risk of blood clots and stroke
- Personal or family history of blood clots
- Smoking
- Obesity
- Systemic lupus erythematosus (SLE)
- Increased risk of heart disease
- Smoking
- Obesity
- High blood pressure
- High blood sugar
- High cholesterol
- Aged 50 or older
- Dementia
- Aged 65 or older
- Pancreas swelling (pancreatitis)
- High levels of triglycerides
- Endometrial cancer
- Using estrogen for more than one year
- Breast cancer
- Personal or family history of breast cancer
- Using estrogen for more than one year
- Increased risk of blood clots and stroke
- Personal or family history of blood clots
- Smoking
- Obesity
- Systemic lupus erythematosus (SLE)
- Increased risk of heart disease
- Smoking
- Obesity
- High blood pressure
- High blood sugar
- High cholesterol
- Age 50 or older
- Dementia
- Age 65 or older
- Pancreas swelling (pancreatitis)
- High levels of triglycerides