Compare Descovy vs. Edurant

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Works with other medicines to treat HIV.

Descovy (emtricitabine / tenofovir alafenamide) is a first choice combination tablet that is used with other medications to treat HIV and is safe for your kidneys and bones.

Works with other medications to treat HIV infection.

Edurant (rilpivirine) is a good HIV drug that has to be used in combination with other HIV medications in patients who are new to treatment or are looking for alternatives to a current HIV regimen.

Upsides
  • Compared to Truvada (a similar drug formulation), Descovy (emtricitabine / tenofovir alafenamide) is safe for your kidneys and bones.
  • Take only once daily, with or without food.
  • Children 12 years or older can take Descovy (emtricitabine / tenofovir alafenamide).
  • Generally well tolerated.
  • Taken only once daily.
  • Edurant (rilpivirine) is available in other combination tablets.
  • Can be used in patients with mild or moderate kidney damage.
Downsides
  • Might worsen hepatitis B infections if you suddenly stop taking Descovy (emtricitabine / tenofovir alafenamide).
  • Descovy (emtricitabine / tenofovir alafenamide) is only approved to treat HIV, not to stop you from getting it.
  • Since Descovy (emtricitabine / tenofovir alafenamide) is not a generic, it may be expensive.
  • Must be taken in combination with other HIV drugs to treat HIV. Cannot be taken alone as treatment.
  • Must be taken with a meal.
  • Cannot be taken with proton pump inhibitors (PPI) like Prilosec or Prevacid. If you need to take an acid reducer, try an antacid like calcium carbonate either 2 hours before or 4 hours after Edurant (rilpivirine). Drugs like Pepcid or Zantac (H2RAs) may also be an option, but these should be taken 12 hours before or 4 hours after Edurant (rilpivirine).
  • Not recommended for patients who have a significantly high level of viral cells or have a very low level of immune cells.
  • Not recommended for children under 12 years old.
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Dosage forms
  • Pill
  • Pill
Price
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$1672.61
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Lowest price
$1044.38
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Reviews
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Side effects
1possible side effects
  • Nausea
    10%
See more detailed side effects
7possible side effects
  • Depressive disorders
    5%
  • Headache
    3%
  • Insomnia
    3%
  • Rash
    3%
  • Abdominal pain
    2%
  • Fatigue
    2%
  • Abnormal dreams
    2%
See more detailed side effects
Risks and risk factors
  • Sudden worsening of Hepatitis B virus (HBV)
    • Hepatitis B virus
  • Lactic acidosis and enlarged, fatty liver
    • Liver disease
    • Obesity
  • Kidney damage
    • History of kidney damage
    • Using other drugs known to harm kidneys
  • Weakened bones
    • History of bone fractures
    • Osteoporosis
  • Immune reconstitution syndrome
    • HIV
    • Exposure to other infections
    • Start of a new HIV medication
    • Change in HIV medication
See more detailed risks and warnings
  • Mood and behavior changes
    • History of mental health problems
  • Immune reconstitution syndrome
    • Exposure to other infections
    • Start of a new HIV medication
    • Change in HIV therapy
  • Fat Redistribution
  • Allergic reactions
    • Prior severe allergic reaction to Edurant (rilpivirine)
  • Liver damage
    • History of liver damage
    • Hepatitis B or C
  • Heart rhythm problems
    • Use with other QT prolonging drugs
    • History of heart disease
    • High doses of Edurant
See more detailed risks and warnings