Compare dexamethasone vs. Humira

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Decadron (dexamethasone)

Prescription only

Humira (adalimumab)

Prescription only
Calms down your immune system.

Decadron (dexamethasone) is a long-acting oral corticosteroid that is very effective in treating allergic reactions and immune conditions, however, if you're taking Decadron (dexamethasone) for a long time, there can be serious side effects.

Calms down the immune system.

Humira (adalimumab) is good for treating many autoimmune conditions, but it can also cause serious side effects.

3.6/ 5 average rating with 182 reviewsforHumira
Upsides
  • Effective in treating many conditions.
  • Can improve energy and appetite.
  • Can control immune responses that are causing you discomfort and works quickly to relieve symptoms like swelling, rash, asthma attacks, and pain.
  • Has long-term benefit in calming down the immune system and keeping it from causing your body harm, such as in autoimmune conditions.
  • Available in generic form.
  • Humira (adalimumab) is effective in reducing symptoms in all of its approved indications.
  • You can give yourself Humira (adalimumab) on your own at home rather than visiting a clinic or hospital.
  • Humira (adalimumab) treats many different autoimmune conditions.
  • Available in a single-use pen (Humira Pen) that may be more convenient and easier for some people to use.
Downsides
  • Many side effects, particularly with long term use.
  • Side effects include mood changes, trouble sleeping and increase in blood pressure and blood sugar at higher doses.
  • Long-term use can cause problems with skin, bone, eye health and put you at a higher risk for infections.
  • If you've been using corticosteroids for more than 2 weeks, you will need to work with a doctor to get off the medicine slowly.
  • Limited studies conducted with use of steroids during pregnancy or breastfeeding - potential harm to unborn baby.
  • Not first-choice treatment for rheumatoid arthritis.
  • Humira (adalimumab) is an injection and not an oral medication.
  • Humira (adalimumab) is expensive because there's no generic available yet.
  • Humira (adalimumab) lowers your ability to fight infection and in some cases can cause serious life-threatening illness. The risk is greater if you take other drugs that lower your immune system, have an active infection, diabetes, or had tuberculosis (TB) in the past.
  • You'll need to properly dispose of the needle, syringes, or Pen in a sharps container.
  • Humira (adalimumab) needs to be refrigerated until you use it, so if you're traveling, you'll need to carry it in a cooler with an ice pack.
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Used for
  • Allergies
  • Skin Conditions
  • Endocrine Conditions
  • Eye Conditions
  • Stomach Conditions
  • Respiratory disorder
  • Multiple sclerosis flare
  • Hematologic Conditions
  • Cancer
  • Autoimmune and Rheumatic Conditions
  • Immune thrombocytopenia
  • Acute mountain sickness
  • Multiple myeloma
  • Prevention of nausea and vomiting from chemotherapy
Dosage forms
  • Pill
  • Liquid
  • Injection
Price
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Reviews
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182 reviews so far
60%
saidit'sworth it
51%
saiditworked well
26%
saidit'sa big hassle

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Side effects
The Decadron (dexamethasone) FDA package insert doesn’t have numbers about how common side effects are.
14possible side effects
  • Upper airway infection
    17%
  • Headache
    12%
  • Rash
    12%
  • Sinus infection
    11%
  • Nausea
    9%
  • Injection site reactions
    8%
  • Urinary tract infection
    8%
  • Flu syndrome
    7%
  • Stomach pain
    7%
  • High cholesterol
    7%
  • Back pain
    6%
  • Blood in urine
    5%
  • Abnormal liver tests
    5%
  • High blood pressure
    5%
See more detailed side effects
Risks and risk factors
  • Lowered adrenal function
    • Lowering dose or stopping too quickly especially after long-term treatment
    • Stress such as trauma, surgery or infection
  • Increased risk for infections
    • Taking other immunosuppressants
    • Long-term treatment
    • Not vaccinated against viral diseases
    • Contact with people who have viral illness
    • History of bacterial or viral conditions
  • Changes in heart and kidney function
    • Recent heart attack
  • Stomach and intestinal problems
    • History of stomach bleeding
    • Active or history of stomach ulcers
    • Ulcerative colitis
    • Taking Decadron (dexamethasone) with other medicine that can cause stomach problems
  • Bone effects
    • Dose of Decadron (dexamethasone)
    • Duration of treatment
  • Eye problems
See more detailed risks and warnings
  • Serious infections
    • Taking other immunosuppressant medications such as Kineret or Orencia
    • Age 65 or older
    • Active, chronic, or recurrent infection
    • Comorbidities
  • Cancers
    • Taking other immunosuppressant medications, such as azathiprine or 6-mercaptopurine, at the same time as Humira (adalimumab)
    • History of malignancy
    • Adolescent age
    • COPD with significant smoking history
  • Serious allergic reactions
  • Heart problems
    • History of heart failure
  • Nervous system effects
    • Preexisting or recently acquired neurologic condition
  • Lower blood cell counts
See more detailed risks and warnings