Compare dexamethasone vs. prednisolone acetate

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Calms down your immune system.

Decadron (dexamethasone) is a long-acting oral corticosteroid that is very effective in treating allergic reactions and immune conditions, however, if you're taking Decadron (dexamethasone) for a long time, there can be serious side effects.

Calms down redness and swelling in the eye.

Omnipred (prednisolone acetate) is a steroid used in the eye that is effective for treatment and symptom relief, but with long-term use, it can have some side effects.

Upsides
  • Effective in treating many conditions.
  • Can improve energy and appetite.
  • Can control immune responses that are causing you discomfort and works quickly to relieve symptoms like swelling, rash, asthma attacks, and pain.
  • Has long-term benefit in calming down the immune system and keeping it from causing your body harm, such as in autoimmune conditions.
  • Available in generic form.
  • Omnipred (prednisolone acetate) works only within the eye, so it will relieve symptoms without having the side effects of oral steroids.
  • Kicks in relatively quickly to relieve symptoms.
  • Available in generic form.
Downsides
  • Many side effects, particularly with long term use.
  • Side effects include mood changes, trouble sleeping and increase in blood pressure and blood sugar at higher doses.
  • Long-term use can cause problems with skin, bone, eye health and put you at a higher risk for infections.
  • If you've been using corticosteroids for more than 2 weeks, you will need to work with a doctor to get off the medicine slowly.
  • Limited studies conducted with use of steroids during pregnancy or breastfeeding - potential harm to unborn baby.
  • Depending on the condition, you might have to use Omnipred (prednisolone acetate) up to 4 times a day, particularly in the beginning.
  • If using Omnipred (prednisolone acetate) long-term, may require some monitoring by your doctor.
  • Contains sulfite, so depending on the severity of your allergy, may not be suitable for those with allergies to sulfite.
  • Long-term use can lead to increased risk of more serious side effects.
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Used for
  • Allergies
  • Skin Conditions
  • Endocrine Conditions
  • Eye Conditions
  • Stomach Conditions
  • Respiratory disorder
  • Multiple sclerosis flare
  • Hematologic Conditions
  • Cancer
  • Autoimmune and Rheumatic Conditions
  • Immune thrombocytopenia
  • Acute mountain sickness
  • Multiple myeloma
  • Prevention of nausea and vomiting from chemotherapy
  • Inflammation of the Eye
  • Eye Injury
  • Allergies
Dosage forms
  • Pill
  • Liquid
  • Liquid
Price
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Reviews
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Side effects
The Decadron (dexamethasone) FDA package insert doesn’t have numbers about how common side effects are.
The Omnipred (prednisolone acetate) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Lowered adrenal function
    • Lowering dose or stopping too quickly especially after long-term treatment
    • Stress such as trauma, surgery or infection
  • Increased risk for infections
    • Taking other immunosuppressants
    • Long-term treatment
    • Not vaccinated against viral diseases
    • Contact with people who have viral illness
    • History of bacterial or viral conditions
  • Changes in heart and kidney function
    • Recent heart attack
  • Stomach and intestinal problems
    • History of stomach bleeding
    • Active or history of stomach ulcers
    • Ulcerative colitis
    • Taking Decadron (dexamethasone) with other medicine that can cause stomach problems
  • Bone effects
    • Dose of Decadron (dexamethasone)
    • Duration of treatment
  • Eye problems
See more detailed risks and warnings
  • Glaucoma and cataracts
  • Increased risk of infection
  • Thinning of eye layer
  • Severe allergic reactions
    • Asthma
See more detailed risks and warnings