Compare Dexilant vs. Aciphex

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Dexilant (dexlansoprazole)

Prescription only

Aciphex (rabeprazole)

Prescription only
Treats heartburn.

Dexilant (dexlansoprazole) is an effective medicine to treat heartburn, but can be expensive since it is only available as a brand.

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4.7/ 5 average rating with 73 reviewsforDexilant
Treats heartburn and ulcers.

Aciphex (rabeprazole) is good for treating heartburn and ulcers, but should not be used long-term.

Upsides
  • Relieves heartburn symptoms better than other stomach medicines (like Pepcid, Tagamet, and Zantac).
  • Lasts longer than other alternative stomach medicines.
  • Convenient once daily dosing.
  • Treats GERD in children 12 to 17 years of age.
  • Can be swallowed whole, or contents of the pill can be emptied into applesauce for easy swallowing.
  • Aciphex (rabeprazole) works better than over-the-counter medications that have not relieved your acid reflux.
  • The delayed-release pill provides relief over 24 hours.
  • Aciphex (rabeprazole) can be taken with or without food.
  • The capsule can be safely used by children as young as 1 year old.
Downsides
  • Similar to other proton pump inhibitors, Dexilant (dexlansoprazole) can weaken bones when taken for a long period of time.
  • Can take a few days before you start to feel the full effects.
  • Dexilant (dexlansoprazole) can affect how other medicines, vitamins, and minerals get absorbed in your body.
  • There's no generic version available, so it can be expensive.
  • Using Aciphex (rabeprazole) for a long time can can weaken your bones or increase your risk for infectious diarrhea.
  • Lowers magnesium and vitamin B12 in your body so you may need to take supplements.
  • Aciphex (rabeprazole) interferes with how many medications work.
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Used for
Dosage forms
  • Delayed-release pill
  • Dissolving tablet
  • Delayed release pill
Price
Lowest price
$194.20
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Lowest price
$10.85
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Reviews
73 reviews so far
93%
saidit'sworth it
92%
saiditworked well
14%
saidit'sa big hassle

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Side effects
6possible side effects
  • Diarrhea
    5%
  • Abdominal pain
    4%
  • Nausea
    3%
  • Upper airway infection
    3%
  • Gas
    3%
  • Vomiting
    2%
See more detailed side effects
5possible side effects
  • Headache
    10%
  • Diarrhea
    5%
  • Nausea
    5%
  • Vomiting
    4%
  • Abdominal pain
    4%
See more detailed side effects
Risks and risk factors
  • Possible stomach cancer
  • Kidney inflammation
  • Severe diarrhea
    • Being hospitalized
    • Antibiotic use
  • Bone fractures
    • High dose Dexilant (dexlansoprazole)
    • Long-term treatment with Dexilant (dexlansoprazole) (more than 1 year)
    • Low bone mineral density
    • Aged 50 years or older
    • Alcohol
    • Smoking
    • Taking steroids or seizure medicines
  • Low magnesium and vitamin B12 levels
    • Taking digoxin or diuretics
  • Lupus
See more detailed risks and warnings
  • Stomach cancer
  • Kidney inflammation
  • Severe diarrhea
    • Being hospitalized
    • Antibiotic use
  • Bone fractures
    • High dose Aciphex (rabeprazole)
    • Taking Aciphex (rabeprazole) for longer than one year
    • Low bone mineral density
    • Age 50 years or older
    • Alcohol
    • Smoking
    • Taking steroids or anti-seizure medicines
  • Low levels of magnesium and vitamin B12
  • Lupus
See more detailed risks and warnings
Learn more about Dexilant (dexlansoprazole)
Learn more about Aciphex (rabeprazole)