Compare Dexilant vs. omeprazole

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Prilosec (omeprazole)

Prescription or OTC
Treats heartburn.

Dexilant (dexlansoprazole) is an effective medicine to treat heartburn, but can be expensive since it is only available as a brand.

4.7/ 5 average rating with 73 reviewsforDexilant
Treats heartburn and excess release of stomach acid.

Prilosec (omeprazole) gives you long-lasting heartburn relief but has some risks if used long term.

4.0/ 5 average rating with 1167 reviewsforomeprazole
Upsides
  • Relieves heartburn symptoms better than other stomach medicines (like Pepcid, Tagamet, and Zantac).
  • Lasts longer than other alternative stomach medicines.
  • Convenient once daily dosing.
  • Treats GERD in children 12 to 17 years of age.
  • Can be swallowed whole, or contents of the pill can be emptied into applesauce for easy swallowing.
  • Prilosec (omeprazole) lasts longer (up to 72 hours) than other classes of acid reducers (like Zantac, Pepcid, or Tums).
  • Only take once or twice daily.
  • Can take together with a quick-acting antacid (like Maalox or Tums) for quick relief.
  • Generic and over-the-counter options available.
  • Safe to use in children ages 1 or older.
Downsides
  • Similar to other proton pump inhibitors, Dexilant (dexlansoprazole) can weaken bones when taken for a long period of time.
  • Can take a few days before you start to feel the full effects.
  • Dexilant (dexlansoprazole) can affect how other medicines, vitamins, and minerals get absorbed in your body.
  • There's no generic version available, so it can be expensive.
  • Takes up to an hour to start noticing the effects of Prilosec (omeprazole).
  • Prilosec (omeprazole) can interact with other drugs. Let your doctor and pharmacist know what medications you're taking before starting Prilosec (omeprazole).
  • Long-term use of Prilosec (omeprazole) can put you at risk for many health issues such as osteoporosis, low magnesium or vitamin B12 levels, and rebound acid secretion (where your body starts to create more acid than before after stoping Prilosec (omeprazole)).
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Used for
Dosage forms
  • Delayed-release pill
  • Dissolving tablet
  • Pill
  • Powder
Price
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Reviews
73 reviews so far
93%
saidit'sworth it
92%
saiditworked well
14%
saidit'sa big hassle

Have you used Dexilant (dexlansoprazole)?

Leave a review
1167 reviews so far
80%
saidit'sworth it
59%
saiditworked well
8%
saidit'sa big hassle

Have you used Prilosec (omeprazole)?

Leave a review
Side effects
6possible side effects
  • Diarrhea
    5%
  • Abdominal pain
    4%
  • Nausea
    3%
  • Upper airway infection
    3%
  • Gas
    3%
  • Vomiting
    2%
See more detailed side effects
11possible side effects
  • Headache
    7%
  • Abdominal pain
    5%
  • Nausea
    4%
  • Diarrhea
    4%
  • Vomiting
    3%
  • Flatulence
    3%
  • Acid regurgitation
    2%
  • Upper respiratory infection
    2%
  • Constipation
    2%
  • Dizziness
    2%
  • Rash
    2%
See more detailed side effects
Risks and risk factors
  • Possible stomach cancer
  • Kidney inflammation
  • Severe diarrhea
    • Being hospitalized
    • Antibiotic use
  • Bone fractures
    • High dose Dexilant (dexlansoprazole)
    • Long-term treatment with Dexilant (dexlansoprazole) (more than 1 year)
    • Low bone mineral density
    • Aged 50 years or older
    • Alcohol
    • Smoking
    • Taking steroids or seizure medicines
  • Low magnesium and vitamin B12 levels
    • Taking digoxin or diuretics
  • Lupus
See more detailed risks and warnings
  • Risk of cancer
  • Lupus
    • History of cutaneous or systemic lupus erythematosus
  • Severe diarrhea associated with C.difficile infection
    • Being hospitalized
    • Antibiotic use
  • Bone fractures
    • Osteoporosis
    • Using high medication doses
    • Long-term therapy (1 year or more)
    • Use of other medications that weaken bones
  • Low Vitamin B12 and Magnesium
    • Taking water pills (Magnesium)
    • Women (Vitamin B12)
    • Over the age of 30 (Vitamin B12)
  • Kidney damage
See more detailed risks and warnings