Compare Dexilant vs. Pepcid

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Pepcid (Famotidine)

Prescription or OTC
Treats heartburn and ulcers.

Dexilant (Dexlansoprazole) is an effective medicine to treat heartburn and ulcers, but can be expensive.

4.7/ 5 average rating with 73 reviewsforDexilant
Relieves heartburn.

Pepcid (Famotidine) works well for heartburn but may not last as long or start working as quickly as other antacids.

3.7/ 5 average rating with 853 reviewsforPepcid
  • Relieves heartburn symptoms and heals ulcers better than other stomach medicines, such as Pepcid, Tagamet, and Zantac.
  • Lasts longer than other similar stomach medicines. Most people take it once a day.
  • Your body won't develop a tolerance to Dexilant (Dexlansoprazole), so it'll work the same way as long as you need to keep taking it.
  • Once heartburn symptoms are treated, a low dose of Dexilant (Dexlansoprazole) can be taken daily.
  • Most people can take Famotidine without any noticeable day-to-day side effects.
  • Famotidine lasts longer than many other antacids like Maalox and Tums, and you only need to take it once or twice a day.
  • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
  • Available as both a generic and over-the-counter option, so it's pretty affordable.
  • Few drug interactions.
  • Taking Dexilant (Dexlansoprazole) in high doses or for longer than 1 year can increase the risk for bone fractures, especially if you already have osteoporosis (weak bones).
  • Many drugs can interact with Dexilant (Dexlansoprazole), so talk to your doctor or pharmacist before starting any new medicines.
  • There's no generic version available, so it can be expensive.
  • Other antacids like Maalox, Tums, or Rolaids often start to work more quickly than Famotidine.
  • Medication like omeprazole (proton pump inhibitors) works better at healing and preventing stomach ulcers than medication like Famotidine (H2 blockers).
  • Can cause more serious side effects for people with kidney disease. Ask your doctor to give you a lower dose or choose a different option.
Used for
Dosage forms
  • Extended release
  • Pill
  • Chewable tablet
  • Liquid
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73 reviews so far
saidit'sworth it
saiditworked well
saidit'sa big hassle

Have you used Dexilant (Dexlansoprazole)?

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853 reviews so far
saidit'sworth it
saiditworked well
saidit'sa big hassle

Have you used Pepcid (Famotidine)?

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Side effects
6possible side effects
  • Diarrhea
  • Abdominal Pain
  • Nausea
  • Upper Respiratory Tract Infection
  • Vomiting
  • Flatulence
See more detailed side effects
2possible side effects
  • Headache
  • Diarrhea
See more detailed side effects
Risks and risk factors
  • Hiding possible cancer
  • Severe stomach inflammation (atrophic gastritis)
    • Helicobacter pylori infection
    • Autoimmune disease
  • Severe diarrhea
    • Being hospitalized
    • Antibiotic use
  • Broken bones
    • Osteoporosis
    • Age 50 or older
    • Using high medication doses
    • Long-term therapy (1 year or more)
    • Smoking
    • Use of other medications that weaken bones
  • Low vitamin or mineral levels
See more detailed risks and warnings
  • Hiding possible cancer
  • Increased side effects
    • Current kidney disease
  • Allergic reaction
See more detailed risks and warnings