Compare Diclofenac vs. tramadol

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Zorvolex (Diclofenac)

Prescription only

Ultram (tramadol)

Prescription only
Treats arthritis pain and swelling.

Zorvolex (Diclofenac) is an okay medication used to treat pain and swelling caused by arthritis. However, because of the risk of heart attack, you should limit the amount you take.

Treats moderate to severe pain.

Ultram (tramadol) works well for pain. Although it's a little weaker than other opioids, it can still be addictive.

3.4/ 5 average rating with 642 reviewsfortramadol
Upsides
  • Clinical studies show that Zorvolex (Diclofenac) is better at relieving arthritis pain than acetaminophen (Tylenol).
  • Can be used as needed to treat pain and swelling.
  • Available as a generic.
  • Relieves moderate to severe pain. It has been shown to work as well as other opioid pain medications.
  • Compared to typical opioids, it provides unique pain relief and effects on your mood when taken regularly.
  • Has a lower chance of causing breathing problems compared to other typical opioids.
  • Doesn't cause as much constipation as other opioid pain medicines. Staying hydrated and taking laxatives can help treat this side effect.
Downsides
  • You should avoid alcohol while on Zorvolex (Diclofenac) since it can increase your risk of stomach issues.
  • If you're taking it on a regular basis, you'll need to get labs done to make sure your liver and kidneys aren't being affected.
  • Some people think it's weaker than other opioid pain medications. It can also cause more upset stomach.
  • Like other opioid pain relievers, Ultram (tramadol) has a high risk of addiction, abuse, misuse, overdose, and death.
  • The extended release version of Ultram (tramadol) should only be used for severe pain that requires daily, around-the-clock treatment once alternative treatments haven't worked.
  • It's a controlled substance regulated by the federal government. This means that your use of Ultram (tramadol) will be tracked to prevent potential prescription abuse.
  • Like all opioids, don't use when pregnant, since the baby can become dependent on it and have withdrawal symptoms after birth.
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Used for
  • Osteoarthritis pain
Dosage forms
  • Pill
  • Pill
  • Extended release
  • Extended release capsule
  • Dissolving tablet
Price
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Reviews
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642 reviews so far
61%
saidit'sworth it
40%
saiditworked well
16%
saidit'sa big hassle

Have you used Ultram (tramadol)?

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Side effects
28possible side effects
  • Upper respiratory tract infection
    8%
  • Headache
    8%
  • Nausea
    7%
  • Urinary tract infection
    7%
  • Diarrhea
    6%
  • Nasopharyngitis
    6%
  • Constipation
    5%
  • Sinusitis
    5%
  • Osteoarthritis
    5%
  • Cough
    4%
  • Alanine aminotransferase increased
    4%
  • Abdominal pain upper
    3%
  • Vomiting
    3%
  • Back pain
    3%
  • Dyspepsia
    3%
  • Procedural pain
    3%
  • Bronchitis
    3%
  • Hypertension
    3%
  • Influenza
    3%
  • Arthralgia
    3%
  • Contusion
    3%
  • Blood creatinine increased
    2%
  • Flatulence
    2%
  • Abdominal discomfort
    2%
  • Aspartate aminotransferase increased
    2%
  • Dizziness
    2%
  • Fall
    2%
  • Abdominal pain
    2%
See more detailed side effects
13possible side effects
  • Dizziness
    26%
  • Nausea
    24%
  • Constipation
    24%
  • Headache
    18%
  • Sleepiness
    16%
  • Vomiting
    9%
  • Pruritus
    8%
  • CNS Stimulation
    7%
  • Asthenia
    6%
  • Sweating
    6%
  • Dyspepsia
    5%
  • Dry Mouth
    5%
  • Diarrhea
    5%
See more detailed side effects
Risks and risk factors
  • Heart attack or stroke
    • History of heart problems
    • High blood pressure
    • High cholesterol
    • Diabetes
    • Being overweight or obese
    • Smoking
  • Stomach bleeding
    • History of stomach bleeding or ulcers
    • Age 65 years or older
  • Bruising or bleeding
    • Bleeding disorder
    • Taking other blood-thinning medications
  • Serious allergic reactions
    • Asthma
    • Rhinitis
    • Nasal polyps
    • Aspirin allergy
    • NSAID allergy
  • Lowers kidney function
    • Kidney problems
    • Heart failure
    • Liver disease
    • Taking diuretics
    • Taking ACE inhibitors or angiotensin receptor blockers (ARBs)
    • Age 65 or older
  • Increased blood pressure
    • History of high blood pressure
    • Taking water pills (diuretics)
See more detailed risks and warnings
  • Breathing problems
    • Age 65 or greater
    • Overdose
    • Using alcohol, benzodiazepines or other medicines that slow breathing
  • Addiction, abuse, and overdose
    • Taking more than the prescribed dose
    • Taking with alcohol or benzodiazepines
    • Stopping Ultram (tramadol) suddenly
  • Interactions with other drugs
  • Withdrawal in newborns
    • Pregnancy
  • Accidental ingestion
    • Children can reach medication
See more detailed risks and warnings