Compare Differin vs. Aczone
Head-to-head comparisons of medication uses, side effects, ratings, and more.
Differin (adapalene) is commonly used for treating acne, but, it can cause skin irritation.
Aczone (dapsone) is a highly safe and effective topical treatment for moderate to severe forms of acne, but may be expensive.
- Differin (adapalene) is a good option for the treatment of acne.
- It is available as a cheaper, generic medication.
- It only has to be applied to the skin once a day at bedtime.
- The 0.1% gel formulation is available over the counter, without a prescription.
- Differin (adapalene) is generally well tolerated, with few side effects.
- Topical application is safe and easy.
- Works well with minimal side effects.
- Once or twice-daily dosing is available for administration that fits your schedule.
- Your skin may look worse before it starts looking better.
- Differin (adapalene) can take up to 8 to 12 week to start working.
- Aczone (dapsone) may not be right for you if you take certain medications or have certain blood conditions.
- No generic available so it may be expensive.
- Results may take up to 12 weeks to be noticed.
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5possible side effects
- Skin dryness42%
- Skin redness38%
- Skin scaling35%
- Persistent burning and stinging24%
- Persistent itching21%
15possible side effects
- Application site reaction18%
- Application site dryness16%
- Mild skin dryness14%
- Mild oiliness or peeling13%
- Application site redness13%
- Mild skin irritation9%
- Moderate oiliness or peeling6%
- Moderate skin irritation5%
- Stuffy nose and throat5%
- Moderate skin dryness3%
- Head cold3%
- Swollen sinuses2%
- Throat swelling2%
Risks and risk factors
- Local skin reactions
- Soaps and cleansers with skin-drying effects
- Products with high concentraions of alcohol, astringents, spices, or limes.
- UV and sunlight exposure
- Severe allergic reaction
- Low red blood cell count
- G6PD deficiency
- Congenital or Idiopathic methemoglobinemia
- Other methemoglobin-inducing agents
- Other effects on blood cells
- G6PD deficiency/oral Dapsone
- antimalarial medications