Compare Differin vs. benzoyl peroxide
Head-to-head comparisons of medication uses, side effects, ratings, and more.
Differin (adapalene) is commonly used for treating acne, but, it can cause skin irritation.
Benzac (benzoyl peroxide) is the most effective over-the-counter treatment for mild acne.
3.4/ 5 average rating with 394 reviewsforbenzoyl peroxide
- Differin (adapalene) is a good option for the treatment of acne.
- It is available as a cheaper, generic medication.
- It only has to be applied to the skin once a day at bedtime.
- The 0.1% gel formulation is available over the counter, without a prescription.
- Differin (adapalene) is generally well tolerated, with few side effects.
- Available over-the-counter from many brands.
- Benzac (benzoyl peroxide) comes in many different forms and combinations with other acne products.
- Your skin may look worse before it starts looking better.
- Differin (adapalene) can take up to 8 to 12 week to start working.
- Benzac (benzoyl peroxide) increases your skin's sensitivity to the sun and may also cause dryness or stinging.
- Be careful when applying Benzac (benzoyl peroxide) to large areas since it can bleach hair, clothing, and pillow cases upon contact.
- Benzac (benzoyl peroxide) needs to be combined with other medications to effectively treat severe acne.
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5possible side effects
- Skin dryness42%
- Skin redness38%
- Skin scaling35%
- Persistent burning and stinging24%
- Persistent itching21%
The Benzac (benzoyl peroxide) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
- Local skin reactions
- Soaps and cleansers with skin-drying effects
- Products with high concentraions of alcohol, astringents, spices, or limes.
- UV and sunlight exposure
- Severe allergic reaction
- Skin irritation
- Using other medicines or products that irritate the skin
- Extreme temperatures (hot or cold)
- Allergic reaction