Compare Differin vs. Cleocin
Head-to-head comparisons of medication uses, side effects, ratings, and more.
Differin (adapalene) is commonly used for treating acne, but, it can cause skin irritation.
Cleocin (clindamycin) is proven to be effective at treating acne when combined with another acne medicine and is available in a variety of formulations.
3.5/ 5 average rating with 115 reviewsforCleocin
- Differin (adapalene) is a good option for the treatment of acne.
- It is available as a cheaper, generic medication.
- It only has to be applied to the skin once a day at bedtime.
- The 0.1% gel formulation is available over the counter, without a prescription.
- Differin (adapalene) is generally well tolerated, with few side effects.
- Available in generic.
- Comes in different formulations (gel, solution, lotion, foam) to fit your preferences.
- Works well for the kind of acne that causes large, red, and swollen pimples.
- Your skin may look worse before it starts looking better.
- Differin (adapalene) can take up to 8 to 12 week to start working.
- Foam formulation can cause headaches.
- You will likely have to use another acne medicine along with Cleocin (clindamycin) since it is not as effective by itself.
- Is only preferred for mild to moderate acne. If you have severe acne your doctor will most likely prescribe an oral medication.
- If you only have comedonal acne (small skin-colored bumps on the skin) without any red, swollen pimples, your doctor may give you an alternative medicine.
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5possible side effects
- Skin dryness42%
- Skin redness38%
- Skin scaling35%
- Persistent burning and stinging24%
- Persistent itching21%
9possible side effects
- Oiliness/Oily skin18%
- Burning where applied6%
Risks and risk factors
- Local skin reactions
- Soaps and cleansers with skin-drying effects
- Products with high concentraions of alcohol, astringents, spices, or limes.
- UV and sunlight exposure
- Severe allergic reaction
- Skin irritation
- Using other medicines or products that irritate the skin
- Extreme temperatures (hot or cold)
- Severe diarrhea and stomach cramps
- Using Cleocin (clindamycin) for a long time