Compare Differin vs. Epiduo

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Treats acne.

Differin (adapalene) is commonly used for treating acne, but, it can cause skin irritation.

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Upsides
  • Differin (adapalene) is a good option for the treatment of acne.
  • It is available as a cheaper, generic medication.
  • It only has to be applied to the skin once a day at bedtime.
  • The 0.1% gel formulation is available over the counter, without a prescription.
  • Differin (adapalene) is generally well tolerated, with few side effects.
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Downsides
  • Your skin may look worse before it starts looking better.
  • Differin (adapalene) can take up to 8 to 12 week to start working.
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Used for
  • Acne vulgaris
Dosage forms
  • Cream
  • Gel
  • Lotion
  • Cream, gel, or ointment
Price
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Reviews
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Side effects
5possible side effects
  • Skin dryness
    42%
  • Skin redness
    38%
  • Skin scaling
    35%
  • Persistent burning and stinging
    24%
  • Persistent itching
    21%
See more detailed side effects
The Epiduo (Adapalene / Benzoyl Peroxide) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Local skin reactions
    • Soaps and cleansers with skin-drying effects
    • Products with high concentraions of alcohol, astringents, spices, or limes.
  • UV and sunlight exposure
  • Severe allergic reaction
See more detailed risks and warnings
No information currently available