Compare Dificid vs. azithromycin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

ADVERTISEMENT

Dificid (fidaxomicin)

Prescription only

Zithromax (azithromycin)

Prescription only
Treats diarrhea caused by C. diff infection.

Dificid (fidaxomicin) works well to treat a severe gut infection caused by the bacterium Clostridium difficile.

Treats bacterial infections.

Zithromax (azithromycin) is good for treating many bacterial infections and is available in generic form. However, it may cause headache, dizziness, or rash.

4.0/ 5 average rating with 909 reviewsforazithromycin
Upsides
  • You only have to take it twice daily, regardless of meal time. You can take it together with other medications. It has minimal side effects.
  • Available as a generic in the tablet and suspension form.
  • The suspension can be used if you have problems swallowing.
  • Used to treat many types of bacterial infections.
  • Bacteria is less resistant to this antibiotic, meaning that Zithromax (azithromycin) will fight off the bacteria better. Your doctor may run tests to see which antibiotics will kill the bacteria causing your infection.
  • Immediate release form can be taken with or without food.
Downsides
  • Dificid (fidaxomicin) is comparatively effective, but costs more than alternatives.
  • Must space out antacids by at least 2 hours.
  • Use with caution if you have liver disease.
  • Must be used with caution if you are on medications to thin the blood (anticoagulants) because of increased risk of bleeding.
ADVERTISEMENT
Used for
Dosage forms
  • Pill
  • Pill
  • Liquid
  • Extended-release liquid
Price
Lowest price
$3664.38
Find instant savings near you
Want to save even more money?
Sign up now for a 30-day trial and save up to 95% at CVS, Kroger, Albertsons, and other pharmacies.
Learn more
Reviews
Not enough review data.Leave a review
909 reviews so far
74%
saidit'sworth it
59%
saiditworked well
11%
saidit'sa big hassle

Have you used Zithromax (azithromycin)?

Leave a review
Side effects
5possible side effects
  • Nausea
    11%
  • Vomiting
    7%
  • Abdominal pain
    6%
  • Bleeding in the gut
    4%
  • Low blood counts
    2%
See more detailed side effects
3possible side effects
  • Vomiting
    5%
  • Diarrhea
    4%
  • Abdominal pain
    2%
See more detailed side effects
Risks and risk factors
  • Appropriate use
  • Serious immediate allergic reaction
  • Cross allergies
    • Macrolide Antibiotic Allergy
See more detailed risks and warnings
  • Diarrhea caused by bacteria (Clostridium difficile)
  • Liver damage
    • History of liver disease
  • Myasthenia gravis
    • Myasthenia gravis
  • Serious allergic reaction
  • Abnormal heartbeat
    • QT prolongation
    • Arrhythmia
    • Drugs that cause prolonged QT interval
    • Abnormal electrolytes
    • Elderly
See more detailed risks and warnings