Compare digoxin vs. Amiodarone

Head-to-head comparisons of medication uses, side effects, ratings, and more.


Lanoxin (digoxin)

Prescription only

Cordarone (Amiodarone)

Prescription only
Improves heart pumping.

Lanoxin (digoxin) is effective at treating heart failure symptoms, but it doesn't lower your risk of death compared to other heart failure medicines.

3.3/ 5 average rating with 70 reviewsfordigoxin
Treats heart rate problems.

Cordarone (Amiodarone) is an option to treat heart rate problems when other medicines don't work, but it can take a few weeks to work and there's a lot of serious side effects.

  • Lanoxin (digoxin) is used for abnormal heart rhythms, and for heart failure that can't be controlled by other medications.
  • Lanoxin (digoxin) does not need dose adjustments with people with liver problems.
  • Lanoxin (digoxin) is available in a generic form.
  • Lanoxin (digoxin) can be taken once daily.
  • An option for treating life-threatening heart rate problems when other medicines or procedures haven't worked.
  • Cordarone (Amiodarone) has been shown to lower the number of heart rate problems you can experience after certain types of heart surgeries.
  • Available as a generic version, so it should be affordable.
  • Lanoxin (digoxin) relieves heart failure symptoms, but doesn't lower your risk of death. It's usually used together with other medicines that help lower the risk of death in heart failure.
  • Use of Lanoxin (digoxin) requires blood tests, especially during the first few weeks of treatment to monitor drug level in the body.
  • If your blood levels of Lanoxin (digoxin) are too high, it can be life threatening.
  • Lanoxin (digoxin) is usually not an option for people with kidney problems.
  • Not a good choice if you have eye, liver, or lung problems.
  • You'll need regular monitoring for side effects, such as routine blood tests, heart tests, and eye exams.
  • Cordarone (Amiodarone) can stay in your body for weeks or months after you've stopped taking it. Make sure you tell your doctor or dentist that you've taken Cordarone (Amiodarone) if they don't already know.
  • There are many possible drug interactions, so talk to your doctor or pharmacist before making any changes or starting a new medicine.
Used for
Dosage forms
  • Pill
  • Liquid
  • Pill
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70 reviews so far
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Side effects
9possible side effects
  • Dizziness
  • Mental disturbances
  • Nausea
  • Diarrhea
  • Headache
  • Death
  • Increased heart rate
  • Vomiting
  • Rash
See more detailed side effects
The Cordarone (Amiodarone) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Irregular heartbeat
    • History of heart problems
    • Drug interactions
    • Wolff-Parkinson-White syndrome
  • Digoxin toxicity
    • Low body weight
    • Elderly (>65 years old)
    • Worsening kidney function
    • Electrolyte imbalances
  • Thyroid imbalance
    • Overactive or underactive thyroid
See more detailed risks and warnings
  • Life-threatening heart rate problems
    • Taking other heart rate medicines
  • Lung damage
  • Liver damage
    • History of liver problems
  • Vision problems
  • Thyroid problems
    • History of thyroid problems
  • Harm to fetus
    • Women of childbearing age
See more detailed risks and warnings