Compare Dilantin vs. Lamictal

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Dilantin (phenytoin)

Prescription only

Lamictal (Lamotrigine)

Prescription only
Treats and prevents seizures.

Dilantin (phenytoin) is very good at treating and preventing seizures, but it has many drug interactions and some serious side effects.

Prevents seizures and stabilizes mood.

Lamictal (Lamotrigine) is most useful for treating severe seizure disorders, and for bipolar disorder with more depression symptoms than manic symptoms. Just be careful to increase your dose slowly to avoid skin rash.

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3.7/ 5 average rating with 184 reviewsforLamictal
Upsides
  • If you have trouble swallowing pills, Dilantin (phenytoin) is available as a chewable tablet or a liquid.
  • Dilantin (phenytoin) is available in a cheaper, generic form.
  • Effective at lowering the frequency of seizures in people with epilepsy or Lennox-Gestaut syndrome. Typically used together with other medications for severe seizure disorders.
  • Works best for partial, tonic-clonic, and absence seizures.
  • A first-line treatment for bipolar disorder. Effective long-term treatment for stabilizing mood. Prevents both depressive and manic episodes, but the effect is greater for preventing depression.
  • Doesn't require routine blood tests.
Downsides
  • Need to get regular blood tests while taking Dilantin (phenytoin) to make sure the medicine level is safe and effective in your body.
  • Can cause changes in your appearance, such as unwanted hair growth and enlargement of your gums.
  • If you have kidney problems, you’ll need regular blood tests to check your kidney function and to make sure Dilantin (phenytoin) levels in your blood don’t get too high.
  • Dilantin (phenytoin) can make other medications not work as well, including birth control.
  • Can cause double vision, dizziness, sleepiness, and headache.
  • Has the risk of a rare but life-threatening rash.
  • Can make hormonal birth control less effective.
  • Might be less effective than other medicines for treating manic episodes (acute mania) in people with bipolar disorder.
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Used for
Dosage forms
  • Extended release
  • Chewable tablet
  • Liquid
  • Pill
  • Extended release
  • Chewable tablet
  • Dissolving tablet
Price
Lowest price
$69.25
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Lowest price
$28.10
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Reviews
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184 reviews so far
66%
saidit'sworth it
58%
saiditworked well
18%
saidit'sa big hassle

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Side effects
The Dilantin (phenytoin) FDA package insert doesn’t have numbers about how common side effects are.
36possible side effects
  • Dizziness
    38%
  • Headache
    28%
  • Diplopia
    28%
  • Ataxia
    22%
  • Nausea
    19%
  • Blurred vision
    16%
  • Somnolence
    14%
  • Rhinitis
    14%
  • Pharyngitis
    10%
  • Rash
    10%
  • Vomiting
    9%
  • Cough increased
    8%
  • Flu syndrome
    7%
  • Dysmenorrhea
    7%
  • Fever
    6%
  • Diarrhea
    6%
  • Incoordination
    6%
  • Insomnia
    6%
  • Abdominal pain
    5%
  • Dyspepsia
    5%
  • Constipation
    4%
  • Tremor
    4%
  • Depression
    4%
  • Anxiety
    4%
  • Vaginitis
    4%
  • Convulsion
    3%
  • Irritability
    3%
  • Speech disorder
    3%
  • Pruritus
    3%
  • Vision abnormality
    3%
  • Neck pain
    2%
  • Reaction aggravated (seizure exacerbation)
    2%
  • Anorexia
    2%
  • Arthralgia
    2%
  • Concentration disturbance
    2%
  • Amenorrhea
    2%
See more detailed side effects
Risks and risk factors
  • Severe skin reactions
    • Asian ancestry
  • Serious liver damage
    • First 2 months of taking Dilantin (phenytoin)
  • Changes in blood cell counts
  • Suicidal thoughts or behavior
    • History of depression
  • Withdrawal seizures
    • Stopping Dilantin (phenytoin) suddenly
See more detailed risks and warnings
  • Suicidal thoughts or behavior
    • History of depression
  • Serious skin rash
    • People also taking Depakote
    • Taking more than the prescribed dose
    • Increasing the dose too quickly
  • Serious allergic reactions
  • Blood disorders
  • Meningitis
  • Interactions with birth control pills
    • Taking birth control pills
  • Withdrawal seizures
    • Stopping Lamictal (Lamotrigine) suddenly
See more detailed risks and warnings
Learn more about Dilantin (phenytoin)
Learn more about Lamictal (Lamotrigine)