Compare Dilantin vs. Vimpat

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Dilantin (phenytoin)

Prescription only

Vimpat (lacosamide)

Prescription only
Treats and prevents seizures.

Dilantin (phenytoin) is very good at treating and preventing seizures, but it has many drug interactions and some serious side effects.

Controls partial seizures.

Vimpat (lacosamide) is considered a first choice medicine to control partial seizures, but it can be expensive since it's brand name.

Upsides
  • If you have trouble swallowing pills, Dilantin (phenytoin) is available as a chewable tablet or a liquid.
  • Dilantin (phenytoin) is available in a cheaper, generic form.
  • Vimpat (lacosamide) is part of the first choice medicines to control partial seizures.
  • Available in pills or liquid to use at home, and as an injectable in the hospital.
  • Can be used by itself or with other medicines to control seizures.
  • There are programs available through the manufacturer that can lower your copay.
Downsides
  • Need to get regular blood tests while taking Dilantin (phenytoin) to make sure the medicine level is safe and effective in your body.
  • Can cause changes in your appearance, such as unwanted hair growth and enlargement of your gums.
  • If you have kidney problems, you’ll need regular blood tests to check your kidney function and to make sure Dilantin (phenytoin) levels in your blood don’t get too high.
  • Dilantin (phenytoin) can make other medications not work as well, including birth control.
  • Only available as a brand name, so it can have a higher copay.
  • There are other medicines similar to Vimpat (lacosamide) that are available as generic and are much cheaper.
  • Vimpat (lacosamide) only works for partial seizures. It can't be used to treat other types of seizures.
  • Vimpat (lacosamide) Is a controlled medicine, so you can only get a limited amount per month.
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Used for
Dosage forms
  • Extended release
  • Chewable tablet
  • Liquid
  • Pill
  • Liquid
  • Injection
Price
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Reviews
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Side effects
The Dilantin (phenytoin) FDA package insert doesn’t have numbers about how common side effects are.
28possible side effects
  • Dizziness
    43%
  • Sleepiness
    26%
  • Nausea
    14%
  • Headache
    13%
  • Fatigue
    12%
  • Double vision
    11%
  • Vomiting
    9%
  • Blurry vision
    8%
  • Difficulty controlling movement
    8%
  • Tremor
    7%
  • Dry mouth
    6%
  • Prickling and tingling sensation
    6%
  • Difficulty controlling eye movements
    5%
  • Prickling and tingling in the mouth
    5%
  • Numbness in the mouth
    5%
  • Loss of balance
    4%
  • Diarrhea
    4%
  • Problems with balance
    4%
  • Itching
    4%
  • Bruising
    3%
  • Skin lacerations
    3%
  • Problems with walking
    3%
  • Chest pain
    3%
  • Problems with coordination
    3%
  • Weakness
    2%
  • Memory problems
    2%
  • Depression
    2%
  • Excessive sweating
    2%
See more detailed side effects
Risks and risk factors
  • Severe skin reactions
    • Asian ancestry
  • Serious liver damage
    • First 2 months of taking Dilantin (phenytoin)
  • Changes in blood cell counts
  • Suicidal thoughts or behavior
    • History of depression
  • Withdrawal seizures
    • Stopping Dilantin (phenytoin) suddenly
See more detailed risks and warnings
  • Suicidal behavior
    • Taking other medicines to control seizures
  • Dizziness and difficulty controlling movements
    • Taking other medicines to control seizures
  • Problems with the heartbeat
    • History of problems with the heartbeat
    • Heart attack
    • Heart failure
    • Heart disease
  • Fainting
    • Taking high doses of Vimpat (lacosamide)
    • Heart disease
    • Taking drugs that slow heart rate
  • Withdrawal seizures
    • Stopping Vimpat (lacosamide) suddenly
  • Severe allergic reactions
See more detailed risks and warnings