Compare Dilaudid vs. Acetaminophen with codeine

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Treats moderate to severe pain.

Dilaudid (hydromorphone) is a powerful pain reliever that has significant risks for abuse and overdose.

4.1/ 5 average rating with 51 reviewsforDilaudid
Treats mild to moderate pain.

Acetaminophen with codeine (acetaminophen / codeine) is a good option to treat pain when over-the-counter medicines aren't enough, but don't take too much acetaminophen (Tylenol) since it can hurt your liver.

3.7/ 5 average rating with 581 reviewsforAcetaminophen with codeine
Upsides
  • Dilaudid (hydromorphone) works better and faster at relieving pain than morphine.
  • Available in a cheap generic version.
  • Combination pain medicine with an opioid component (codeine) and non-opioid component (acetaminophen or Tylenol) that takes advantage of different modes of pain relief in a single pill.
  • Provides quick relief for mild to moderate pain.
  • Good for as-needed pain and control.
  • Generally well tolerated, especially if taken with food to lower risk of stomach upset.
  • Lower rates of misuse compared to pure opioid medicines.
Downsides
  • Constipation is a common side effect of Dilaudid (hydromorphone) and may require the use of laxatives or stool softeners.
  • Dilaudid (hydromorphone) is fatal when combined with alcohol, muscle relaxants, and other medications that slow breathing.
  • Long-term use of opioids will cause physical dependence.
  • Dizziness and drowsiness is common, but your body may adjust.
  • Many people get constipated taking Acetaminophen with codeine (acetaminophen / codeine).
  • All opioid containing medicines have the risk of addiction and withdrawal when used long-term.
  • Acetaminophen (Tylenol) has a high risk of liver failure and death if you take more than the maximum daily dose. Be very careful since many over-the-counter medicines also have acetaminophen.
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Used for
  • Pain management
Dosage forms
  • Pill
  • Extended release pill
  • Liquid
  • Suppository
  • Pill
  • Liquid
Price
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Reviews
51 reviews so far
78%
saidit'sworth it
65%
saiditworked well
10%
saidit'sa big hassle

Have you used Dilaudid (hydromorphone)?

Leave a review
581 reviews so far
69%
saidit'sworth it
41%
saiditworked well
9%
saidit'sa big hassle

Have you used Acetaminophen with codeine (acetaminophen / codeine)?

Leave a review
Side effects
The Dilaudid (hydromorphone) FDA package insert doesn’t have numbers about how common side effects are.
The Acetaminophen with codeine (acetaminophen / codeine) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Slowed breathing
    • Current use of medicine that affects liver enzyme CYP 3A4
    • Age 65 or greater
    • Higher doses
    • Drinking alcohol
    • Use with benzodiazepines
  • Death from overdose
    • Children age 18 and younger
  • Death of newborn babies from opioid withdrawal
    • Long-term use during pregnancy
  • Tolerance, dependence, and addiction
    • Taking more than the prescribed dose
    • Long-term use
    • History of drug abuse
  • Driving impairment
    • Taking Dilaudid (hydromorphone) with alcohol
    • Taking other medicines that make you less alert
    • Age 65 or greater
See more detailed risks and warnings
  • Liver failure and death
    • Alcohol use
    • Taking over-the-counter medicines with acetaminophen
    • History of liver disease
  • High risk to children
  • Use with other CNS depressants
    • Use with alcohol
    • Use with benzodiazepines
    • Use with other opiates
  • Severe allergic reaction
See more detailed risks and warnings