Compare Dilaudid vs. Percocet

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Treats moderate to severe pain.

Dilaudid (hydromorphone) is a powerful pain reliever that has significant risks for abuse and overdose.

4.1/ 5 average rating with 51 reviewsforDilaudid
Treats moderate to severe pain.

Percocet (Oxycodone / Acetaminophen) is the strongest prescription combination pain medicine for as needed pain relief, but make sure you don't take too much acetaminophen (Tylenol) to avoid liver problems or death.

3.8/ 5 average rating with 1399 reviewsforPercocet
Upsides
  • Dilaudid (hydromorphone) works better and faster at relieving pain than morphine.
  • Available in a cheap generic version.
  • Combination pain medicine with an opioid component (oxycodone) and non-opioid component (acetaminophen or Tylenol) that takes advantage of different modes of pain relieve in a single pill.
  • Provides quick relief for moderate to severe pain to improve quality of life.
  • Generally considered stronger than Norco or other combination pain medicine for treating pain.
  • Good for as-needed, short-term use, but may be helpful to manage more long-term pain problems if used at the appropriate doses and intervals.
  • Lower rates of misuse compared to pure opioid medicines.
  • Can help you fall asleep easier.
Downsides
  • Constipation is a common side effect of Dilaudid (hydromorphone) and may require the use of laxatives or stool softeners.
  • Dilaudid (hydromorphone) is fatal when combined with alcohol, muscle relaxants, and other medications that slow breathing.
  • Long-term use of opioids will cause physical dependence.
  • Dizziness and drowsiness is common, but your body may adjust.
  • Everyone will get constipation - always stay hydrated and take stool softener or stimulant on days you're taking Percocet if you need.
  • All opioid containing medicines have the risk of physical dependence and possibility of withdrawal when used long-term.
  • The non-opioid part of Percocet, acetaminophen (Tylenol), has a high risk of liver failure and death if you take more than the maximum daily dose. Be very careful.
  • Relies on the users to be aware of how much acetaminophen (Tylenol) they are using since it is a very common ingredient in many prescription and non-prescription pain medicines.
  • Avoid alcohol.
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Used for
Dosage forms
  • Pill
  • Extended release pill
  • Liquid
  • Suppository
  • Pill
  • Oral solution
Price
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Reviews
51 reviews so far
78%
saidit'sworth it
65%
saiditworked well
10%
saidit'sa big hassle

Have you used Dilaudid (hydromorphone)?

Leave a review
1399 reviews so far
70%
saidit'sworth it
49%
saiditworked well
15%
saidit'sa big hassle

Have you used Percocet (Oxycodone / Acetaminophen)?

Leave a review
Side effects
The Dilaudid (hydromorphone) FDA package insert doesn’t have numbers about how common side effects are.
The Percocet (Oxycodone / Acetaminophen) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Slowed breathing
    • Current use of medicine that affects liver enzyme CYP 3A4
    • Age 65 or greater
    • Higher doses
    • Drinking alcohol
    • Use with benzodiazepines
  • Death from overdose
    • Children age 18 and younger
  • Death of newborn babies from opioid withdrawal
    • Long-term use during pregnancy
  • Tolerance, dependence, and addiction
    • Taking more than the prescribed dose
    • Long-term use
    • History of drug abuse
  • Driving impairment
    • Taking Dilaudid (hydromorphone) with alcohol
    • Taking other medicines that make you less alert
    • Age 65 or greater
See more detailed risks and warnings
  • Death from liver failure
    • Current liver disease
    • Taking with alcohol
    • Taking other medicines with acetaminophen
  • Death from lack of oxygen to the body (respiratory depression)
    • Age 65 or greater
    • Higher dose
    • People with not enough thyroid hormones
    • History of lung problems
  • Driving impairment
    • Taking with alcohol
    • Taking other medicines that make you less alert
    • Age 65 or greater
  • Tolerance and dependence
    • Taking more than the prescribed dose
    • Long-term use
    • History of drug abuse
  • Neonatal withdrawal syndrome
    • Long-term use of opioids in mother
    • Breastfeeding while taking Percocet (Oxycodone / Acetaminophen)
  • Death from overdose (extended-release tablet)
    • Children age 18 and younger
    • Taking more than prescribed dose
    • Mixing with alcohol or drugs that interact with Percocet (Oxycodone / Acetaminophen)
  • Severe allergic reactions
  • Low blood pressure
    • Age 65 years or older
    • Circulation problems
See more detailed risks and warnings