Compare Diltiazem vs. Lisinopril

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Cardizem (Diltiazem)

Prescription only

Zestril (lisinopril)

Prescription only
Lowers blood pressure and controls heart rate.

Diltiazem works well to lower blood pressure and prevent chest pain, but you have to be okay with avoiding alcohol. You can't miss doses, and you might get persistent swelling.

3.5/ 5 average rating with 105 reviewsforDiltiazem
Lowers blood pressure.

Zestril (lisinopril) is a good blood pressure-lowering medicine that protects kidney function.

3.8/ 5 average rating with 687 reviewsforLisinopril
Upsides
  • A first-choice blood pressure treatment for many people.
  • Calcium channel blockers work especially well for African Americans to lower blood pressure.
  • You can take it alone or with other medicines to help lower blood pressure.
  • Lowers the risk of heart attack and stroke.
  • Prevents heart-related chest pain (angina) if you take it regularly.
  • Treats certain abnormal heart rhythms.
  • A first-choice blood pressure treatment for many people.
  • Lowers the risk of heart attack and stroke.
  • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
  • Recommended for anyone with heart failure since it lowers the risk of death and further damage to your heart.
  • Very cheap drug, and comes available as a liquid for children over 6 years of age.
Downsides
  • Calcium channel blockers can cause swelling in your limbs. If this happens for you, it probably won't get better over time, so talk to your doctor about alternatives if it bothers you.
  • Women are more likely to have side effects (especially swelling) from Diltiazem than men.
  • You can't miss doses. Stopping Diltiazem suddenly can cause your blood pressure to go up suddenly, which raises the risk of heart attack and stroke.
  • Some brands of Diltiazem have to be taken with food, so listen carefully for instructions from your doctor or pharmacist.
  • Not a good medication for you if you drink alcohol.
  • Up to 10% of people can get a dry cough while using this medicine. It ranges from a mild tickle in the throat to a persistent hacking cough.
  • Requires a yearly blood test to see how the medicine is affecting your body.
  • Zestril (lisinopril) isn't safe to use if you're pregnant.
  • Doesn't work as well in people of African descent, and can cause a greater chance of face, tongue, or lip swelling.
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Used for
Dosage forms
  • Pill
  • Extended release
  • Extended release capsule
  • Pill
  • Liquid
Price
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Reviews
105 reviews so far
52%
saidit'sworth it
49%
saiditworked well
16%
saidit'sa big hassle

Have you used Cardizem (Diltiazem)?

Leave a review
687 reviews so far
61%
saidit'sworth it
51%
saiditworked well
14%
saidit'sa big hassle

Have you used Zestril (lisinopril)?

Leave a review
Side effects
6possible side effects
  • Edema
    5%
  • Headache
    5%
  • Dizziness
    4%
  • Asthenia
    3%
  • First degree AV block
    2%
  • Bradycardia
    2%
See more detailed side effects
1possible side effects
  • Low blood pressure
    5%
See more detailed side effects
Risks and risk factors
  • Skin rashes
  • Abnormally slow heart rate
    • Taking digoxin or beta-blockers at the same time
  • Sudden liver disease
    • History of liver disease
See more detailed risks and warnings
  • Harm to fetus
    • Women of childbearing age
  • Cough
  • Swelling of face and head
    • African descent
  • High potassium
    • Current kidney problems
    • Medicines that increase potassium
    • Use of salt substitutes
  • Worsening kidney problems
    • History of kidney problems
  • Low blood pressure
    • Taking with alcohol
    • Taking other medicines that lower your blood pressure
See more detailed risks and warnings