Compare Divigel vs. Femring

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Relieves hot flashes due to menopause.

Divigel (Estradiol gel) is an easy to use medicine that comes in 3 different strengths. It uses lower doses of estrogen than other hormone replacements.

Relieves hot flashes and vaginal dryness due to menopause.

Femring (estradiol acetate vaginal ring) is dosed more conveniently than other forms of estrogen therapy (pills, gels, patches, and creams), but needs to be inserted directly into the vagina.

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2.6/ 5 average rating with 31 reviewsforFemring
Upsides
  • Replaces estrogen to your whole body and relieves multiple symptoms due to low estrogen, like hot flashes and vaginal dryness.
  • Good for people who don't want to or can't take daily pills.
  • Can take the easy to use, pre-measured packets anywhere.
  • Divigel (Estradiol gel) has fewer side effects than pills since there are lower amounts of estrogen in gels.
  • In studies, many women on the lowest dose started to feel better about a month after starting the medicine. People using the highest doses felt better in just 2 weeks.
  • Femring (estradiol acetate vaginal ring) may be more convenient since it is dosed once every 3 months compared to other medications that need to taken daily or twice weekly.
  • Many women find Femring (estradiol acetate vaginal ring) more comfortable to use and easier to apply than creams or gels.
  • Unlike other topical therapies, Femring (estradiol acetate vaginal ring) works to improve both hot flashes and vaginal dryness caused by menopause.
Downsides
  • Increases your risk of endometrial and breast cancer.
  • If you have your uterus, you have to use Divigel (Estradiol gel) with another hormone called progestin to lower your risk of uterine cancer.
  • Can't be used in people with liver problems.
  • It's possible to expose other people to the estrogen before it's absorbed by your skin.
  • Can be expensive since it's only available as a brand name product.
  • Use of a vaginal ring might not be the best option if you have a narrow vagina or frequent vaginal infections.
  • The ring can fall out without you noticing.
  • Only available as brand name, so it may be expensive if not covered by insurance.
  • All estrogen therapies increase your risk of uterine cancer, heart problems, and blood clots – especially if you have a history of these conditions.
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Used for
Dosage forms
  • Gel
  • Vaginal ring
Price
Lowest price
$101.04
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Lowest price
$476.23
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Reviews
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31 reviews so far
39%
saidit'sworth it
16%
saiditworked well
19%
saidit'sa big hassle

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Side effects
5possible side effects
  • Breast pain
    6%
  • Unusual vaginal bleeding
    6%
  • Common cold
    4%
  • Lung infection
    2%
  • Yeast infection
    2%
See more detailed side effects
8possible side effects
  • Spotting
    8%
  • Headache
    7%
  • Bloating
    7%
  • Vaginal yeast infection
    6%
  • Breast tenderness
    6%
  • Back pain
    6%
  • Sinus infection
    2%
  • Pain in the uterus
    2%
See more detailed side effects
Risks and risk factors
  • Endometrial cancer
    • Using estrogen for more than one year
  • Breast cancer
    • Personal or family history of breast cancer
    • Using estrogen for more than one year
  • Increased risk of blood clots and stroke
    • Personal or family history of blood clots
    • Smoking
    • Obesity
    • Systemic lupus erythematosus (SLE)
  • Increased risk of heart disease
    • Smoking
    • Obesity
    • High blood pressure
    • High blood sugar
    • High cholesterol
    • Age 50 or older
  • Dementia
    • Age 65 or older
  • Pancreas swelling (pancreatitis)
    • High levels of triglycerides
See more detailed risks and warnings
  • Uterine cancer
    • Using estrogen for more than one year
    • Higher dose of estrogen
  • Breast cancer
    • Personal or family history of breast cancer
    • Using estrogen and progestin for more than one year
  • Blood clots and stroke
    • Personal or family history of blood clots
    • Smoking
    • Obesity
    • Systemic lupus erythematosus (SLE)
  • Heart disease
    • Smoking
    • Obesity
    • High blood pressure
    • High blood sugar
    • High cholesterol
    • Age 50 or older
  • Dementia
    • Age 65 or older
  • Inflammation of pancreas
    • High levels of triglycerides
See more detailed risks and warnings
Learn more about Divigel (Estradiol gel)
Learn more about Femring (estradiol acetate vaginal ring)