Compare Doxepin vs. Butisol

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Zonalon (Doxepin)

Prescription only

Butisol (butabarbital)

Prescription only
Helps you stop itching.

Zonalon (Doxepin) works well treating itchy skin, but could make you sleepy.

Helps you fall asleep.

Butisol (butabarbital) is not very good for sleeping problems because it can be addictive.

Upsides
  • In clinical trials, Zonalon (Doxepin) was found to be the most effective cream for treating itchy skin.
  • You can use Zonalon (Doxepin) for up to 8 days at a time.
  • Butisol (butabarbital) works very quickly to help you fall asleep, within 45-60 minutes, and it lasts 6-8 hours.
Downsides
  • You need a prescription for Zonalon (Doxepin).
  • It isn't available as a generic, so it could be kind of pricey.
  • Zonalon (Doxepin) can make you sleepy.
  • Zonalon (Doxepin) can interact with other medications, vitamins, or alternative treatments.
  • Your body can get used to needing Butisol (butabarbital) for sleeping.
  • Butisol (butabarbital) can interact with a lot of medicines, vitamins and supplements.
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Used for
Dosage forms
  • Cream, gel, or ointment
  • Pill
Price
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Reviews
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Side effects
The Zonalon (Doxepin) FDA package insert doesn’t have numbers about how common side effects are.
1possible side effects
  • Sleepiness
    3%
See more detailed side effects
Risks and risk factors
  • Addiction and tolerance
  • Behavior changes
  • Feeling awake
    • Having acute or chronic pain
    • age 65 or older
  • Breathing problems
    • Drinking alcohol
    • Taking narcotics, tranquilizers or antihistamines
See more detailed risks and warnings