Compare doxepin vs. Hetlioz

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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doxepin

Prescription only

Hetlioz (tasimelteon)

Prescription only
Treats depression and anxiety.

doxepin can treat depression and anxiety, but it's not a first choice medication because of its many side effects.

Keeps the sleep cycle normal for completely blind people who aren't able to see light.

Hetlioz (tasimelteon) is the only approved medicine to help completely blind people who are unable to see light maintain regular sleep cycles. It is only available as a brand name, so it can be expensive.

Upsides
  • doxepin has been consistently shown to improve symptoms of depression and anxiety.
  • doxepin has been used to treat depression for over forty years.
  • Hetlioz (tasimelteon) is not addictive.
  • Hetlioz (tasimelteon) is the only drug that's approved to help people unable to see light to have regular sleep cycles.
  • If you have to stop taking Hetlioz (tasimelteon) suddenly, you're not likely to have withdrawal.
Downsides
  • doxepin can make you very sleepy. Try taking it at bedtime if you need to be alert during the day.
  • You shouldn't drink alcohol with doxepin. It can worsen side effects like drowsiness.
  • You have to take it daily, especially if you are feeling better, for the medicine to do its job.
  • It can have more side effects than other antidepressants, like weight gain and increased appetite, decreased libido, and sleepiness.
  • It's not unusual for people to try different antidepressants until they find one that works for them.
  • Hetlioz (tasimelteon) can take weeks to months for you to notice any effect.
  • Hetlioz (tasimelteon) is only available as a brand name so it can be expensive.
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Used for
  • Non-24 hour sleep-wake cycle
Dosage forms
  • Pill
  • Liquid
  • Pill
Price
Lowest price
$14445.07
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Reviews
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Side effects
The doxepin FDA package insert doesn’t have numbers about how common side effects are.
5possible side effects
  • Headache
    17%
  • Abnormal liver tests
    10%
  • Nightmares or abnormal dreams
    10%
  • Common cold or flu
    7%
  • Urinary tract infection
    7%
See more detailed side effects
Risks and risk factors
  • Suicidal thoughts or behavior
    • Age 24 years or under
  • Unmasking of bipolar disorder
    • Bipolar disorder
  • Serotonin syndrome
    • Taking MAOIs (monoamine oxidase inhibitors)
  • Heart problems
    • History of heart disease
    • Adults over 65
    • Electrolyte imbalance
  • Sleepiness
    • Adults 65 years or older
    • Taking other medicines that cause drowsiness (antihistamines, sleep medications, narcotic pain medications)
    • Alcohol
  • Dizziness and falls
    • Age 65 years or older
See more detailed risks and warnings