Compare Doxepin vs. Pamelor

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Zonalon (Doxepin)

Prescription only

Pamelor (Nortriptyline)

Prescription only
Helps you stop itching.

Zonalon (Doxepin) works well treating itchy skin, but could make you sleepy.

Improves your mood.

Pamelor (Nortriptyline) is a good option for treating depression, especially for people who also have problems with persistent nerve pain.

4.0/ 5 average rating with 19 reviewsforPamelor
Upsides
  • In clinical trials, Zonalon (Doxepin) was found to be the most effective cream for treating itchy skin.
  • You can use Zonalon (Doxepin) for up to 8 days at a time.
  • Helpful with treating certain types of pain, like migraines or nerve-related pain.
  • Generally well tolerated and has fewer side effects than other medicines in the same class of drugs.
Downsides
  • You need a prescription for Zonalon (Doxepin).
  • It isn't available as a generic, so it could be kind of pricey.
  • Zonalon (Doxepin) can make you sleepy.
  • Zonalon (Doxepin) can interact with other medications, vitamins, or alternative treatments.
  • Side effects are usually manageable, but can be annoying.
  • Increases the risk of falls, especially when used in the elderly.
  • There's an increased chance of it causing heart problems, especially in people with a history of heart problems.
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Used for
Dosage forms
  • Cream, gel, or ointment
  • Pill
  • Liquid
Price
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Reviews
Not enough review data.Leave a review
19 reviews so far
79%
saidit'sworth it
79%
saiditworked well
21%
saidit'sa big hassle

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Side effects
The Zonalon (Doxepin) FDA package insert doesn’t have numbers about how common side effects are.
The Pamelor (Nortriptyline) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Suicidal thoughts or behavior
    • Age 24 years or younger
  • Low blood pressure
    • Age 65 years or older
  • Withdrawal
    • Stopping Pamelor (Nortriptyline) suddenly
  • Serotonin syndrome
    • Using other medications that affect serotonin
  • Heart problems
    • History of heart disease
    • Older age
    • Electrolyte imbalance
See more detailed risks and warnings