Compare doxepin vs. Surmontil
Head-to-head comparisons of medication uses, side effects, ratings, and more.
Treats depression and anxiety.
doxepin can treat depression and anxiety, but it's not a first choice medication because of its many side effects.
Improves your mood.
Surmontil (trimipramine) is good at treating depression, but it can cause more side effects, like sleepiness and weight gain, compared to other medicines.
Upsides
- doxepin has been consistently shown to improve symptoms of depression and anxiety.
- doxepin has been used to treat depression for over forty years.
- Surmontil (trimipramine) is part of the first choice medicines to treat depression.
- Available in generic and in three different strengths.
- Can be taken once a day, usually before you go to bed.
- Can be taken with or without food.
Downsides
- doxepin can make you very sleepy. Try taking it at bedtime if you need to be alert during the day.
- You shouldn't drink alcohol with doxepin. It can worsen side effects like drowsiness.
- You have to take it daily, especially if you are feeling better, for the medicine to do its job.
- It can have more side effects than other antidepressants, like weight gain and increased appetite, decreased libido, and sleepiness.
- It's not unusual for people to try different antidepressants until they find one that works for them.
- You might not notice changes in your mood until you've taken Surmontil (trimipramine) for several weeks.
- Stopping Surmontil (trimipramine) suddenly without telling your doctor can be dangerous.
- Surmontil (trimipramine) can cause more side effects than other medicines used to treat depression.
Used for
Dosage forms
- Pill
- Liquid
- Pill
Price
Lowest price
$7.95
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$34.06
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Reviews
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Side effects
The doxepin FDA package insert doesn’t have numbers about how common side effects are.
The Surmontil (trimipramine) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
- Suicidal thoughts or behavior
- Age 24 years or under
- Unmasking of bipolar disorder
- Bipolar disorder
- Serotonin syndrome
- Taking MAOIs (monoamine oxidase inhibitors)
- Heart problems
- History of heart disease
- Adults over 65
- Electrolyte imbalance
- Sleepiness
- Adults 65 years or older
- Taking other medicines that cause drowsiness (antihistamines, sleep medications, narcotic pain medications)
- Alcohol
- Dizziness and falls
- Age 65 years or older
- Higher risk of suicide
- People under age 24
- Possible bipolar disorder
- Serotonin syndrome
- Tricyclic antidepressants
- Fentanyl
- Tramadol
- Buspirone
- ADHD medicines
- Triptans
- SSRI antidepressants
- Heart problems
- History of heart disease
- Drowsiness or sleepiness
- Withdrawal symptoms