Compare Duetact vs. Kazano

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Lowers blood sugar.

Duetact (pioglitazone / glimepiride) combines 2 different anti-diabetic medicines into one to help improve blood sugar control, but it is associated with serious complications such as heart failure.

Lowers blood sugar.

Kazano (alogliptin / metformin) takes advantage of 2 medicines combined into one to lower your blood sugar, but you can develop tolerance if you have been taking this medication for a long time or at high doses.

  • Taken only once a day.
  • Effectively lowers A1c levels and greatly improves blood sugar control as a combination medicine compared to taking the 2 individual medicines alone.
  • Duetact (pioglitazone / glimepiride) is a good add-on treatment option for people who are unable to fully control their blood sugar levels through diet and exercise alone.
  • Duetact (pioglitazone / glimepiride) is an oral medicine so it might be a good alternative for those who don't like injections.
  • Lowers A1c levels by 1.2-1.6%.
  • Can be taken by mouth instead of using an injection.
  • Less likely to cause weight gain and low blood sugar compared to other diabetes medications.
  • Generic available, may be more affordable than others in it's class.
  • Duetact (pioglitazone / glimepiride) might cause weight gain.
  • Might not be a good treatment option for people with heart failure or liver problems.
  • Might cause bone fractures, especially for women.
  • Relatively expensive as a combination medicine compared to the 2 individual medicines alone.
  • Not recommended for people age 65 or older and those with kidney problems because they are more likely to experience side effects such as low blood sugar.
  • Rare but serious side effects include pancreatitis and severe joint pain.
  • Tolerance can happen with Kazano (alogliptin / metformin) if you have been taking this drug for a long time or at high doses, it may not work as well and you may need higher doses to get the same effect.
  • Heart failure and worsening heart failure has been linked to Kazano (alogliptin / metformin).
  • The chance of low blood sugar may be raised when Kazano (alogliptin / metformin) is used with other medications for diabetes.
Used for
Dosage forms
  • Pill
  • Pill
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Side effects
The Duetact (pioglitazone / glimepiride) FDA package insert doesn’t have numbers about how common side effects are.
7possible side effects
  • Upper respiratory tract infection
  • Common cold
  • Diarrhea
  • High blood pressure
  • Headache
  • Back pain
  • Urinary tract infection
See more detailed side effects
Risks and risk factors
  • Fluid retention and heart failure
    • Those with a history of heart failure
  • Low blood sugar
    • Skipping meals or having inconsistent meal times
    • Drinking alcohol
    • Using other blood sugar-lowering medicines
    • People age 60 or older
    • Those with kidney problems
  • Bone fractures
    • Females
  • Effect on liver function
    • Those with a history of liver problems
  • Bladder cancer
    • Those with active bladder cancer or a history of it
  • Severe allergic reaction
See more detailed risks and warnings
  • Danger from lactic acid build up (lactic acidosis)
    • Kidney problems
    • Liver problems
    • Congestive heart failure
    • Using contrast dye for procedures
    • Surgery
    • Alcohol use
  • inflammation of pancreas
    • History of pancreatitis
    • History of gallstones
    • Alcoholism
    • Elevated triglycerides
  • Heart failure
    • Heart failure
    • Congestive heart failure
    • Heart disease
  • Severe allergic reactions
  • Liver problems
    • Liver problems
    • Liver disease
  • Severe joint pain
See more detailed risks and warnings