Compare Duricef vs. Keflex

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Duricef (cefadroxil)

Prescription only

Keflex (cephalexin)

Prescription only
Treats bacterial infections.

Duricef (cefadroxil) is good for treating many bacterial infections and is available as a generic. However, if you're taking blood thinners, you could be more likely to bleed.

Treats bacterial infections.

Keflex (cephalexin) is good for treating many bacterial infections, and is available as a generic.

3.7/ 5 average rating with 686 reviewsforKeflex
Upsides
  • Duricef (cefadroxil) is available as a generic.
  • Available in different forms: tablet, capsule, and suspension.
  • Used to treat many types of bacterial infections.
  • Can be taken with or without food.
  • Generally few side effects compared with other antibiotics.
  • Available in generic.
  • Available in different forms: tablet, capsule, and suspension.
  • Used to treat many types of bacterial infections.
  • Can be taken with or without food.
  • Generally few side effects compared with other antibiotics.
Downsides
  • If you're taking blood thinners, let your doctor know. Duricef (cefadroxil) can interact with your medicines and make you more likely to bleed.
  • May not be a good option if you have colitis or other digestive tract problems. Ask your doctor.
  • Duricef (cefadroxil) can also affect certain lab tests, let all your healthcare providers know that you're on Duricef (cefadroxil).
  • Can cause diarrhea.
  • You may need to take Keflex (cephalexin) 2 to 4 times a day, which can be hard to remember.
  • If you're allergic to penicillins or other antibiotics, you might not be able to take this medicine.
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Used for
Dosage forms
  • Pill
  • Liquid
  • Pill
  • Liquid
Price
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Reviews
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686 reviews so far
64%
saidit'sworth it
48%
saiditworked well
14%
saidit'sa big hassle

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Side effects
The Duricef (cefadroxil) FDA package insert doesn’t have numbers about how common side effects are.
The Keflex (cephalexin) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Penicillin allergy
    • History of penicillin allergy
  • New infection
    • Taking Duricef (cefadroxil) for a long time
  • Kidney problems
    • Kidney problems
    • Kidney disease
    • Hemodialysis
  • Diarrhea
See more detailed risks and warnings
  • Diarrhea
  • New infections while taking Keflex (cephalexin)
    • Weakened immune system
    • Not taking Keflex (cephalexin) correctly
  • Allergic reaction
    • History of penicillin or cephalosporin allergies
See more detailed risks and warnings