Compare Effexor vs. Cymbalta
Head-to-head comparisons of medication uses, side effects, ratings, and more.
Improves mood and helps you relax.
Effexor (venlafaxine) is good for treating depression and anxiety, but it can cause more withdrawal symptoms if you stop suddenly compared to other antidepressants.
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3.7/ 5 average rating with 577 reviewsforEffexor
Improves mood and relieves certain types of pain.
Cymbalta (duloxetine) is good for treating depression, anxiety, and some forms of chronic pain, but it is more likely than other antidepressants to cause problems if you drink alcohol or have high blood pressure.
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3.6/ 5 average rating with 496 reviewsforCymbalta
Upsides
- Effexor (venlafaxine) effectively treats depression, anxiety, and panic disorder.
- Effexor (venlafaxine) causes more sleepiness than other antidepressants, so it's beneficial for people who have trouble sleeping.
- Effexor (venlafaxine) might work when other antidepressants haven't worked since it affects two chemicals in the brain that impact your mood.
- Effexor (venlafaxine) has several uses, which may be good for people with multiple conditions.
- Effexor (venlafaxine) is available in generic, which is cheaper.
- Cymbalta (duloxetine) may help relieve nerve pain from diabetes and other forms of chronic pain.
- Cymbalta (duloxetine) has several uses, which may be good for people with multiple conditions.
- Available as a generic, which is cheaper.
Downsides
- Effexor (venlafaxine) can cause side effects such as decreased libido and increased blood pressure.
- Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people aged 24 years or younger.
- Compared to other antidepressants, it's more likely to cause unpleasant withdrawal symptoms if you suddenly stop taking it and can causes more sleepiness.
- Cymbalta (duloxetine) may not be a good option if you're a heavy drinker, or have liver or kidney problems.
- Cymbalta (duloxetine) can increase high blood pressure.
- Like most antidepressants, Cymbalta (duloxetine) can cause higher risk of suicidal thoughts and behavior for people aged 24 and younger.
Used for
- Depression
- Anxiety
- Diabetic neuropathy (nerve damage)
- Fibromyalgia
- Chronic muscle pain
- Urinary incontinence (women)
Dosage forms
- Pill
- Extended release
- Pill
- Extended release
Price
Lowest price
$11.99
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$12.51
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Reviews
577 reviews so far
62%
saidit'sworth it
51%
saiditworked well
23%
saidit'sa big hassle
Have you used Effexor (venlafaxine)?
Leave a review496 reviews so far
58%
saidit'sworth it
49%
saiditworked well
24%
saidit'sa big hassle
Have you used Cymbalta (duloxetine)?
Leave a reviewSide effects
39possible side effects
- Nausea37%
- Headache25%
- Drowsiness23%
- Dry mouth22%
- Dizziness19%
- Difficulty sleeping18%
- Constipation15%
- Nervousness13%
- Weakness12%
- Sweating12%
- Abnormal ejaculation/orgasm12%
- Loss of appetite11%
- Diarrhea8%
- Infection6%
- Vomiting6%
- Anxiety6%
- Blurred vision6%
- Impotence6%
- Indigestion5%
- Tremor5%
- Abnormal dreams4%
- Chills3%
- Rash3%
- Gas3%
- Stiff muscles3%
- Prickling/burning sensation3%
- Yawn3%
- Increased urination3%
- Chest pain2%
- Trauma2%
- Increased blood pressure2%
- Increased heart rate2%
- Decreased libido2%
- Agitation2%
- Confusion2%
- Thinking abnormal2%
- Changes in taste2%
- Ringing in the ears2%
- Dilation of pupils2%
12possible side effects
- Nausea23%
- Headache14%
- Dry mouth13%
- Drowsiness10%
- Fatigue9%
- Difficulty sleeping9%
- Constipation9%
- Dizziness9%
- Diarrhea9%
- Decreased appetite7%
- Excessive sweating6%
- Abdominal pain5%
Risks and risk factors
- Suicidal thoughts or behavior
- Age 24 years or younger
- Serotonin syndrome
- Taking tricyclic antidepressants, lithium, tramadol, fentanyl, amphetamines, certain headache medications (triptans), St. John's Wort
- Withdrawal
- Stopping Effexor (venlafaxine) suddenly
- Increased bleeding
- Taking other blood-thinning drugs (including aspirin, NSAIDs such as Advil, warfarin)
- Increased blood pressure
- Bipolar disorder
- History of bipolar disorder
- At risk for bipolar disorder
- Suicidal thoughts or behavior
- Age 24 years or younger
- Serotonin syndrome
- Taking tricyclic antidepressants, lithium, tramadol, fentanyl, amphetamines, certain headache medications (triptans), St. John's Wort
- Withdrawal
- Stopping Cymbalta (duloxetine) abruptly
- Increased bleeding
- Taking other blood-thinning drugs (including aspirin, NSAIDs such as Advil, warfarin)
- Changes in blood pressure and risk of falls
- Elderly patients
- History of gait disturbances
- Taking more than 60 mg of Cymbalta (duloxetine) daily
- Taking other medicines that lower blood pressure
- History of high blood pressure
- Bipolar disorder
- History of bipolar disorder
- At risk for bipolar disorder