Compare Effexor vs. Fioricet

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Improves mood and helps you relax.

Effexor (venlafaxine) is good for treating depression and anxiety, but it can cause more withdrawal symptoms if you stop suddenly compared to other antidepressants.

3.7/ 5 average rating with 577 reviewsforEffexor
Treats tension headaches.

Fioricet (Butalbital / Acetaminophen / Caffeine) works well for tension headaches, but isn’t recommended due to the ability to overuse it and have withdrawal symptoms.

4.3/ 5 average rating with 17 reviewsforFioricet
Upsides
  • Effexor (venlafaxine) effectively treats depression, anxiety, and panic disorder.
  • Effexor (venlafaxine) causes more sleepiness than other antidepressants, so it's beneficial for people who have trouble sleeping.
  • Effexor (venlafaxine) might work when other antidepressants haven't worked since it affects two chemicals in the brain that impact your mood.
  • Effexor (venlafaxine) has several uses, which may be good for people with multiple conditions.
  • Effexor (venlafaxine) is available in generic, which is cheaper.
  • Fioricet (Butalbital / Acetaminophen / Caffeine) works better and faster in treating tension headaches than the combination of acetaminophen and codeine.
  • Fioricet (Butalbital / Acetaminophen / Caffeine) doesn’t cost much since it's available as a generic medication.
  • Fioricet (Butalbital / Acetaminophen / Caffeine) has very few side effects.
  • It has been widely used for a long time.
Downsides
  • Effexor (venlafaxine) can cause side effects such as decreased libido and increased blood pressure.
  • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people aged 24 years or younger.
  • Compared to other antidepressants, it's more likely to cause unpleasant withdrawal symptoms if you suddenly stop taking it and can causes more sleepiness.
  • Fioricet (Butalbital / Acetaminophen / Caffeine) isn't the first choice medication for treating tension headaches.
  • It's not a good medication for long-term use.
  • Overuse of Fioricet (Butalbital / Acetaminophen / Caffeine) can lead to chronic tension headaches.
  • Fioricet (Butalbital / Acetaminophen / Caffeine) can cause dangerous withdrawal symptoms, intoxication, and dependence.
  • Taking Fioricet (Butalbital / Acetaminophen / Caffeine) can decrease your ability to drive a car, or operate machinery.
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Used for
Dosage forms
  • Pill
  • Extended release
  • Pill
  • Oral solution
Price
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Reviews
577 reviews so far
62%
saidit'sworth it
51%
saiditworked well
23%
saidit'sa big hassle

Have you used Effexor (venlafaxine)?

Leave a review
17 reviews so far
88%
saidit'sworth it
76%
saiditworked well
12%
saidit'sa big hassle

Have you used Fioricet (Butalbital / Acetaminophen / Caffeine)?

Leave a review
Side effects
39possible side effects
  • Nausea
    37%
  • Headache
    25%
  • Drowsiness
    23%
  • Dry mouth
    22%
  • Dizziness
    19%
  • Difficulty sleeping
    18%
  • Constipation
    15%
  • Nervousness
    13%
  • Weakness
    12%
  • Sweating
    12%
  • Abnormal ejaculation/orgasm
    12%
  • Loss of appetite
    11%
  • Diarrhea
    8%
  • Infection
    6%
  • Vomiting
    6%
  • Anxiety
    6%
  • Blurred vision
    6%
  • Impotence
    6%
  • Indigestion
    5%
  • Tremor
    5%
  • Abnormal dreams
    4%
  • Chills
    3%
  • Rash
    3%
  • Gas
    3%
  • Stiff muscles
    3%
  • Prickling/burning sensation
    3%
  • Yawn
    3%
  • Increased urination
    3%
  • Chest pain
    2%
  • Trauma
    2%
  • Increased blood pressure
    2%
  • Increased heart rate
    2%
  • Decreased libido
    2%
  • Agitation
    2%
  • Confusion
    2%
  • Thinking abnormal
    2%
  • Changes in taste
    2%
  • Ringing in the ears
    2%
  • Dilation of pupils
    2%
See more detailed side effects
The Fioricet (Butalbital / Acetaminophen / Caffeine) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Suicidal thoughts or behavior
    • Age 24 years or younger
  • Serotonin syndrome
    • Taking tricyclic antidepressants, lithium, tramadol, fentanyl, amphetamines, certain headache medications (triptans), St. John's Wort
  • Withdrawal
    • Stopping Effexor (venlafaxine) suddenly
  • Increased bleeding
    • Taking other blood-thinning drugs (including aspirin, NSAIDs such as Advil, warfarin)
  • Increased blood pressure
    • Bipolar disorder
      • History of bipolar disorder
      • At risk for bipolar disorder
    See more detailed risks and warnings
    • Liver damage
      • Drinking more than 2 alcoholic beverages a day
      • Taking with other acetaminophen-containing medicines
      • History of liver disease
    • Hypersensitivity (allergic) reactions
    See more detailed risks and warnings