Compare Effexor vs. Xanax

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Effexor (venlafaxine)

Prescription only

Xanax (alprazolam)

Prescription only
Improves mood and helps you relax.

Effexor (venlafaxine) is good for treating depression and anxiety, but it can cause more withdrawal symptoms if you stop suddenly compared to other antidepressants.

3.7/ 5 average rating with 577 reviewsforEffexor
Helps you relax.

Xanax (alprazolam) effectively treats occasional or short-term anxiety and panic attacks. Compared to similar drugs, it is more likely to cause withdrawal symptoms and can have more interactions with some medicines.

3.9/ 5 average rating with 1287 reviewsforXanax
Upsides
  • Effexor (venlafaxine) effectively treats depression, anxiety, and panic disorder.
  • Effexor (venlafaxine) causes more sleepiness than other antidepressants, so it's beneficial for people who have trouble sleeping.
  • Effexor (venlafaxine) might work when other antidepressants haven't worked since it affects two chemicals in the brain that impact your mood.
  • Effexor (venlafaxine) has several uses, which may be good for people with multiple conditions.
  • Effexor (venlafaxine) is available in generic, which is cheaper.
  • Xanax (alprazolam) can be used to manage anxiety associated with depression.
  • Works very quickly - in hours.
  • Available in generic.
Downsides
  • Effexor (venlafaxine) can cause side effects such as decreased libido and increased blood pressure.
  • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people aged 24 years or younger.
  • Compared to other antidepressants, it's more likely to cause unpleasant withdrawal symptoms if you suddenly stop taking it and can causes more sleepiness.
  • Use of Xanax (alprazolam) can cause memory problems, drowsiness, dizziness, and confusion.
  • Xanax (alprazolam) can be habit-forming, so it's not typically used for long-term treatment.
  • Compared to other similar drugs, Xanax (alprazolam) is more likely to cause withdrawal symptoms if you take it for a long time and then stop suddenly.
  • If you have liver problems, Xanax (alprazolam) may not be the best choice since it is processed by the liver. Several drugs can also interfere with how Xanax (alprazolam) works. Talk to your doctor to see if Xanax (alprazolam) is right for you.
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Used for
Dosage forms
  • Pill
  • Extended release
  • Pill
  • Extended release
  • Dissolving tablet
  • Liquid
Price
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Reviews
577 reviews so far
62%
saidit'sworth it
51%
saiditworked well
23%
saidit'sa big hassle

Have you used Effexor (venlafaxine)?

Leave a review
1287 reviews so far
74%
saidit'sworth it
55%
saiditworked well
13%
saidit'sa big hassle

Have you used Xanax (alprazolam)?

Leave a review
Side effects
39possible side effects
  • Nausea
    37%
  • Headache
    25%
  • Drowsiness
    23%
  • Dry mouth
    22%
  • Dizziness
    19%
  • Difficulty sleeping
    18%
  • Constipation
    15%
  • Nervousness
    13%
  • Weakness
    12%
  • Sweating
    12%
  • Abnormal ejaculation/orgasm
    12%
  • Loss of appetite
    11%
  • Diarrhea
    8%
  • Infection
    6%
  • Vomiting
    6%
  • Anxiety
    6%
  • Blurred vision
    6%
  • Impotence
    6%
  • Indigestion
    5%
  • Tremor
    5%
  • Abnormal dreams
    4%
  • Chills
    3%
  • Rash
    3%
  • Gas
    3%
  • Stiff muscles
    3%
  • Prickling/burning sensation
    3%
  • Yawn
    3%
  • Increased urination
    3%
  • Chest pain
    2%
  • Trauma
    2%
  • Increased blood pressure
    2%
  • Increased heart rate
    2%
  • Decreased libido
    2%
  • Agitation
    2%
  • Confusion
    2%
  • Thinking abnormal
    2%
  • Changes in taste
    2%
  • Ringing in the ears
    2%
  • Dilation of pupils
    2%
See more detailed side effects
24possible side effects
  • Drowsiness
    41%
  • Lightheadedness
    21%
  • Dry mouth
    15%
  • Depression
    14%
  • Headache
    13%
  • Confusion
    10%
  • Constipation
    10%
  • Diarrhea
    10%
  • Nausea/vomiting
    10%
  • Difficulty sleeping
    9%
  • Fast heartbeat
    8%
  • Nasal congestion
    7%
  • Blurry vision
    6%
  • Low blood pressure
    5%
  • Nervousness
    4%
  • Increased salivation
    4%
  • Muscle rigidity
    4%
  • Tremor
    4%
  • Skin irritation/allergy
    4%
  • Fainting
    3%
  • Weight gain
    3%
  • Dizziness
    2%
  • Restlessness
    2%
  • Weight loss
    2%
See more detailed side effects
Risks and risk factors
  • Suicidal thoughts or behavior
    • Age 24 years or younger
  • Serotonin syndrome
    • Taking tricyclic antidepressants, lithium, tramadol, fentanyl, amphetamines, certain headache medications (triptans), St. John's Wort
  • Withdrawal
    • Stopping Effexor (venlafaxine) suddenly
  • Increased bleeding
    • Taking other blood-thinning drugs (including aspirin, NSAIDs such as Advil, warfarin)
  • Increased blood pressure
    • Bipolar disorder
      • History of bipolar disorder
      • At risk for bipolar disorder
    See more detailed risks and warnings
    • Decreased breathing from use with opioids
      • Taking Xanax (alprazolam) with opioids, drugs or alcohol
      • Using Xanax (alprazolam) for a longer duration and at high doses
    • Dependence and withdrawal
      • History of substance abuse
      • Taking with alcohol or drugs
      • Taking more than 4 mg/day or longer than 12 weeks
      • Stopping Xanax (alprazolam) suddenly
    • Suicidal thoughts or behavior
      • Severe depression
    • Driving impairment
      • Taking with alcohol or drugs
    • Drug interactions
      • Current liver problems
      • Taking medicines such as antifungals, cimetidine, or some HIV medicines
    See more detailed risks and warnings